Hee-Jung Park1, Christian Hampp, Joseph L Demer. 1. Zanvyl Krieger Children's Eye Center, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abstract
PURPOSE: To determine the normative rate of cup-to-disc-ratio (C:D) progression in children and the effect of prematurity and low birth weight on this rate. METHOD: In a single pediatric ophthalmology practice, a single examiner evaluated optic cup size by serial ophthalmoscopy over a minimum of 5 years in 92 patients (184 eyes) without intraocular surgery or optic nerve disease. A cross-sectional analysis of C:D was performed per year of age from 0 to 10 years and linear regression was used to compare C:D progression between preterm and term children and between low versus normal birth weight children. RESULTS: Children exhibited progressive optic cupping. In term children, mean C:D increased by 0.0075 per year. Rate of mean C:D progression was double in children born preterm: 0.0160 (P = .049, comparison to term) per age-year. A similar, nonsignificant trend is observed when comparing low birth weight to normal children (P = .131). CONCLUSION: Prematurity and low birth weight are associated with increased rate of cupping in children. Clinicians should recognize that C:D progression is not a specific sign of glaucoma in children. Copyright 2011, SLACK Incorporated.
PURPOSE: To determine the normative rate of cup-to-disc-ratio (C:D) progression in children and the effect of prematurity and low birth weight on this rate. METHOD: In a single pediatric ophthalmology practice, a single examiner evaluated optic cup size by serial ophthalmoscopy over a minimum of 5 years in 92 patients (184 eyes) without intraocular surgery or optic nerve disease. A cross-sectional analysis of C:D was performed per year of age from 0 to 10 years and linear regression was used to compare C:D progression between preterm and term children and between low versus normal birth weight children. RESULTS:Children exhibited progressive optic cupping. In term children, mean C:D increased by 0.0075 per year. Rate of mean C:D progression was double in children born preterm: 0.0160 (P = .049, comparison to term) per age-year. A similar, nonsignificant trend is observed when comparing low birth weight to normal children (P = .131). CONCLUSION: Prematurity and low birth weight are associated with increased rate of cupping in children. Clinicians should recognize that C:D progression is not a specific sign of glaucoma in children. Copyright 2011, SLACK Incorporated.
Authors: Noriko Miyake; Joseph L Demer; Sherin Shaaban; Caroline Andrews; Wai-Man Chan; Stephen P Christiansen; David G Hunter; Elizabeth C Engle Journal: Invest Ophthalmol Vis Sci Date: 2011-08-11 Impact factor: 4.799
Authors: Joseph L Demer; Robert A Clark; Soh Youn Suh; JoAnn A Giaconi; Kouros Nouri-Mahdavi; Simon K Law; Laura Bonelli; Anne L Coleman; Joseph Caprioli Journal: Invest Ophthalmol Vis Sci Date: 2017-08-01 Impact factor: 4.799