| Literature DB >> 2066944 |
L S Scheinbart1, M A Johnson, L A Gross, S R Edelstein, B C Richardson.
Abstract
Procainamide, a widely used antiarrythmic, causes DNA hypomethylation in the human T cell line Jurkat, but the mechanism is unknown. We report that procainamide inhibits the DNA methyltransferase catalyzed transfer of methyl groups from S-adenosylmethionine to DNA, but has no effect on other known regulators of DNA methylation. Our results suggest that procainamide could inhibit cellular DNA methylation by inhibiting DNA methyltransferase activity.Entities:
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Year: 1991 PMID： 2066944
Source DB: PubMed Journal: J Rheumatol ISSN： 0315-162X Impact factor: 4.666