Literature DB >> 20667734

Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors.

Cui Ling1, Zhibing Zheng, Xian Cheng Jiang, Wu Zhong, Song Li.   

Abstract

Based on a homology-modeled structure of PLTP and characteristic structural features of reported cholesteryl ester transfer protein (CETP) inhibitors, we designed and synthesized a novel series of 2,4,5-trisubstituted selenazole compounds. Biological evaluation reveals that compounds 12 and 17 exhibit favorable PLTP activity, and their IC(50)s are 8 microM and 10 microM, respectively. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20667734     DOI： 10.1016/j.bmcl.2010.07.017

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Stereochemically probing the photo-Favorskii rearrangement: a mechanistic investigation.

Authors:  Richard S Givens; Marina Rubina; Kenneth F Stensrud
Journal:  J Org Chem       Date:  2012-10-24       Impact factor: 4.354

2.  N-p-Tolyl-1,3-selenazolo[5,4-b]pyridin-2-amine.

Authors:  Zhaojun Wu; Yiqun Li; Hua Zhou; Meiyun Zhou
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-09-04

3.  N-(2-Bromo-phen-yl)-1,3-selenazolo[5,4-b]pyridin-2-amine.

Authors:  Zhou Bo; Huang Du Shu; Liu Wei; Zhou Mei Yun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-09-12

4.  An enzymatic route to selenazolines.

Authors:  Jesko Koehnke; Falk Morawitz; Andrew F Bent; Wael E Houssen; Sally L Shirran; Matthew A Fuszard; Iain A Smellie; Catherine H Botting; Margaret C M Smith; Marcel Jaspars; James H Naismith
Journal:  Chembiochem       Date:  2013-02-18       Impact factor: 3.164
  4 in total

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