| Literature DB >> 20667727 |
Caroline Da Ros Montes D'Oca1, Tatiane Coelho, Tamara Germani Marinho, Carolina Rosa Lopes Hack, Rodrigo da Costa Duarte, Pedro Almeida da Silva, Marcelo Gonçalves Montes D'Oca.
Abstract
This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H(37)Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 microg/mL for resistance strains. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20667727 DOI： 10.1016/j.bmcl.2010.06.149
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823