OBJECTIVES: This study evaluated the relationships between estimated glomerular filtration rate (eGFR) and carotid atherosclerosis, peripheral arterial disease (PAD), arterial stiffness, and left ventricular hypertrophy, independent of albuminuria. METHODS: The study population consisted of 6694 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2009. The common carotid artery intima-media thickness (CCA-IMT), carotid plaque, ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and left ventricular mass index (LVMI) of each subjects was assessed. RESULTS: After adjustment for risk factors and albumin-creatinine ratio (ACR), kidney dysfunction (eGFR=30-44 ml/min per 1.73 m2) was significantly associated with carotid plaque presence (odds ratio [OR], 1.75; 95% confidence interval [CI], 1.21-2.53) and PAD (OR, 2.64; 95% CI, 1.51-4.62) compared to normal kidney function (eGFR≥60 ml/min per 1.73 m2). Similarly, mean LVMI and baPWV differed significantly according to eGFR after adjustment for other risk factors and ACR; in contrast, no significant difference was observed for CCA-IMT. CONCLUSIONS: Independent of albuminuria, eGFR is associated with carotid plaque, PAD, baPWV, and LVMI but not with CCA-IMT in Koreans aged 50 years and older.
OBJECTIVES: This study evaluated the relationships between estimated glomerular filtration rate (eGFR) and carotid atherosclerosis, peripheral arterial disease (PAD), arterial stiffness, and left ventricular hypertrophy, independent of albuminuria. METHODS: The study population consisted of 6694 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2009. The common carotid artery intima-media thickness (CCA-IMT), carotid plaque, ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and left ventricular mass index (LVMI) of each subjects was assessed. RESULTS: After adjustment for risk factors and albumin-creatinine ratio (ACR), kidney dysfunction (eGFR=30-44 ml/min per 1.73 m2) was significantly associated with carotid plaque presence (odds ratio [OR], 1.75; 95% confidence interval [CI], 1.21-2.53) and PAD (OR, 2.64; 95% CI, 1.51-4.62) compared to normal kidney function (eGFR≥60 ml/min per 1.73 m2). Similarly, mean LVMI and baPWV differed significantly according to eGFR after adjustment for other risk factors and ACR; in contrast, no significant difference was observed for CCA-IMT. CONCLUSIONS: Independent of albuminuria, eGFR is associated with carotid plaque, PAD, baPWV, and LVMI but not with CCA-IMT in Koreans aged 50 years and older.
Authors: Frank Kuo; Hannah Gardener; Chuanhui Dong; Digna Cabral; David Della-Morte; Susan H Blanton; Mitchell S V Elkind; Ralph L Sacco; Tatjana Rundek Journal: Stroke Date: 2012-05-01 Impact factor: 7.914
Authors: Tatjana Rundek; Susan H Blanton; Susanne Bartels; Chuanhui Dong; Ami Raval; Ryan T Demmer; Digna Cabral; Mitchell S V Elkind; Ralph L Sacco; Moise Desvarieux Journal: Stroke Date: 2013-05-23 Impact factor: 7.914