| Literature DB >> 20666443 |
Anne Cochi1, Thomas-Xavier Métro, Domingo Gomez Pardo, Janine Cossy.
Abstract
An organo-catalyzed Henry reaction, applied to an alpha-keto ester, has allowed the enantioselective synthesis of SSR 241586, a 2,2-disubstituted morpholine active in the treatment of schizophrenia and irritable bowel syndrome (IBS).Entities:
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Year: 2010 PMID： 20666443 DOI： 10.1021/ol101555g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005