One-step synthesis of quinazolino[3,2-a]quinazolinones via palladium-catalyzed domino addition/carboxamidation reactions.

A highly efficient palladium-catalyzed domino process has been developed for the synthesis of quinazolino[3,2-a]quinazolinones by forming five new bonds in a single step. Despite the high density and variety of functional groups on the substrates, the tetracyclic quinazolinones were obtained in good to excellent yields.