PURPOSE OF REVIEW: This review aims to describe recent research on perioperative microvascular alterations, with an emphasis on direct visualization of the human microcirculation. RECENT FINDINGS: Despite systemic haemodynamic optimization, perioperative complications are still occurring. In surgery, recent studies on both direct visualization of the microcirculation and indirect quantification of organ perfusion revealed that both the surgical procedure itself and perioperative interventions like anaesthesia, cardiopulmonary bypass, vasoactive drugs and fluid therapy may influence organ perfusion at the microvascular level. As in sepsis and heart failure, these perioperative microcirculatory abnormalities were associated with prognosis. However, whether these microcirculatory alterations are culprit or bystander in the process of developing perioperative complications remains to be established. SUMMARY: Recent research has elucidated the incidence of perioperative microvascular alterations, as well as its association with prognosis. Future research should further unravel the fascinating and complex interplay between the microcirculation and perioperative interventions.
PURPOSE OF REVIEW: This review aims to describe recent research on perioperative microvascular alterations, with an emphasis on direct visualization of the human microcirculation. RECENT FINDINGS: Despite systemic haemodynamic optimization, perioperative complications are still occurring. In surgery, recent studies on both direct visualization of the microcirculation and indirect quantification of organ perfusion revealed that both the surgical procedure itself and perioperative interventions like anaesthesia, cardiopulmonary bypass, vasoactive drugs and fluid therapy may influence organ perfusion at the microvascular level. As in sepsis and heart failure, these perioperative microcirculatory abnormalities were associated with prognosis. However, whether these microcirculatory alterations are culprit or bystander in the process of developing perioperative complications remains to be established. SUMMARY: Recent research has elucidated the incidence of perioperative microvascular alterations, as well as its association with prognosis. Future research should further unravel the fascinating and complex interplay between the microcirculation and perioperative interventions.
Authors: Christoph R Behem; Michael F Graessler; Till Friedheim; Rahel Kluttig; Hans O Pinnschmidt; Anna Duprée; E Sebastian Debus; Daniel A Reuter; Sabine H Wipper; Constantin J C Trepte Journal: Sci Rep Date: 2021-04-28 Impact factor: 4.379
Authors: D Hutschala; K Skhirtladze; C Kinstner; M Zeitlinger; W Wisser; W Jaeger; M Hoeferl; M Müller; E Tschernko Journal: Antimicrob Agents Chemother Date: 2013-04-15 Impact factor: 5.191
Authors: Zühre Uz; Can Ince; Philippe Guerci; Yasin Ince; Renata P Araujo; Bulent Ergin; Matthias P Hilty; Thomas M van Gulik; Bas A de Mol Journal: Perioper Med (Lond) Date: 2018-08-09