Literature DB >> 20665199

The lipid A receptor.

Kiyoshi Takeda1.   

Abstract

The lipid A receptor consists of several subunits. Lipopolysaccharide binding protein (LBP) is a serum protein facilitating association of lipid A with CD14. The Lipid A-LBP-CD14 complex is further delivered to Toll-like receptor 4 (TLR4), which is essential for lipid A-mediated cellular activation. TLR4 associates with MD-2, which is required for surface expression and recognition of lipid A. In addition, the RP 10S-MD-1 complex mediates TLR4-mediated response in B cells and negatively regulates TLR4-mediated response in dendritic cells. Thus, lipid A receptor's function varies among cell populations.

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Year:  2010        PMID： 20665199     DOI： 10.1007/978-1-4419-1603-7_5

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  4 in total

1.  IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells.

Authors:  Fang Zhou; Bogoljub Ciric; Hongmei Li; Yaping Yan; Ke Li; Melissa Cullimore; Elisabetta Lauretti; Patricia Gonnella; Guang-Xian Zhang; Abdolmohamad Rostami
Journal:  Eur J Immunol       Date:  2012-05-23       Impact factor: 5.532

2.  Annexin A5 binds to lipopolysaccharide and reduces its endotoxin activity.

Authors:  Jacob H Rand; Xiao-Xuan Wu; Elaine Y Lin; Alexander Griffel; Philip Gialanella; John C McKitrick
Journal:  mBio       Date:  2012-03-13       Impact factor: 7.867

3.  Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5.

Authors:  Cheng Wang; Mingqiang Shen; Naixin Zhang; Song Wang; Yang Xu; Shilei Chen; Fang Chen; Ke Yang; Ting He; Aiping Wang; Yongping Su; Tianmin Cheng; Jinghong Zhao; Junping Wang
Journal:  Sci Rep       Date:  2016-03-10       Impact factor: 4.379

4.  The interaction of MD-2 with small molecules in huanglian jiedu decoction play a critical role in the treatment of sepsis.

Authors:  Guirong Chen; Xiaobo Wang; Chang Liu; Mingbo Zhang; Xueying Han; Yubin Xu
Journal:  Front Pharmacol       Date:  2022-09-09       Impact factor: 5.988
  4 in total

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