Literature DB >> 20664875

Synthesis of MUC1-lipopeptide chimeras.

Brendan L Wilkinson1, Lara R Malins, Candy K Y Chun, Richard J Payne.   

Abstract

An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation strategy.

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Year:  2010        PMID： 20664875     DOI： 10.1039/c0cc01360a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Synthesis and Immunological Evaluation of a Multicomponent Cancer Vaccine Candidate Containing a Long MUC1 Glycopeptide.

Authors:  Nitin T Supekar; Vani Lakshminarayanan; Chantelle J Capicciotti; Anju Sirohiwal; Cathy S Madsen; Margreet A Wolfert; Peter A Cohen; Sandra J Gendler; Geert-Jan Boons
Journal:  Chembiochem       Date:  2017-11-30       Impact factor: 3.164

2.  Significance of Proline Residue on Short Mucin Peptide Interactions with Mouse MUC1 Monoclonal Antibody Studied by Saturation Transfer Difference NMR Spectroscopy.

Authors:  Cheng Her; William M Westler; Thao Yang
Journal:  JSM Chem       Date:  2013-10-17

3.  Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide.

Authors:  Pamela Thompson; Vani Lakshminarayanan; Nitin T Supekar; Judy M Bradley; Peter A Cohen; Margreet A Wolfert; Sandra J Gendler; Geert-Jan Boons
Journal:  Chem Commun (Camb)       Date:  2015-05-29       Impact factor: 6.222

4.  Recent Development in Carbohydrate Based Anti-cancer Vaccines.

Authors:  Zhaojun Yin; Xuefei Huang
Journal:  J Carbohydr Chem       Date:  2012-02-29       Impact factor: 1.667

Review 5.  Peptide Lipidation - A Synthetic Strategy to Afford Peptide Based Therapeutics.

Authors:  Renata Kowalczyk; Paul W R Harris; Geoffrey M Williams; Sung-Hyun Yang; Margaret A Brimble
Journal:  Adv Exp Med Biol       Date:  2017       Impact factor: 2.622

Review 6.  Synthetic self-adjuvanting glycopeptide cancer vaccines.

Authors:  David M McDonald; Scott N Byrne; Richard J Payne
Journal:  Front Chem       Date:  2015-10-23       Impact factor: 5.221

Review 7.  Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines.

Authors:  Qingjiang Li; Zhongwu Guo
Journal:  Molecules       Date:  2018-06-29       Impact factor: 4.411

8.  Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System.

Authors:  Mikkel H S Marqvorsen; Can Araman; Sander I van Kasteren
Journal:  Bioconjug Chem       Date:  2019-10-18       Impact factor: 4.774

9.  Multifunctional Protein Conjugates with Built-in Adjuvant (Adjuvant-Protein-Antigen) as Cancer Vaccines Boost Potent Immune Responses.

Authors:  Jing-Jing Du; Chang-Wei Wang; Wen-Bo Xu; Lian Zhang; Yuan-Kai Tang; Shi-Hao Zhou; Xiao-Fei Gao; Guang-Fu Yang; Jun Guo
Journal:  iScience       Date:  2020-02-24
  9 in total

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