Alexander V Sergeev1, David O Carpenter. 1. School of Public Health Sciences and Professions, Ohio University, Athens, Ohio 45701, USA. sergeev@ohio.edu
Abstract
BACKGROUND: Evidence is emerging that exposure to persistent organic pollutants (POP) is a risk factor for atherosclerosis-related diseases and for diabetes mellitus (DM). We hypothesized that residential proximity to sources of POP will be associated with an increase in hospitalization rates for ischemic stroke (IS) with comorbid DM (IS-DM). METHODS: We examined IS-DM hospitalization rates in the New York State (exclusive of New York City) during a 12-year period. POP exposure status was assessed based on residency in a zip code containing or abutting environmental sources of POP. Adjusted relative risks (RR) of IS-DM hospitalization were estimated by multivariate Poisson regression. RESULTS: A statistically significant 10% increase in IS-DM hospitalization rates was observed in populations environmentally exposed to POP (adjusted RR 1.10, 95% confidence interval, CI, 1.01-1.20; p = 0.031). IS-DM hospitalization rates were also higher in males (adjusted RR 1.34, 95% CI 1.30-1.39; p < 0.001), in blacks (adjusted RR 4.54, 95% CI 4.16-4.94; p < 0.001) and in older age groups (p for trend <0.001). CONCLUSIONS: Residential proximity to sources of POP is associated with an increase in RR of IS-DM hospitalization. Our findings support the hypothesis of POP being a risk factor for IS. Further studies are warranted.
BACKGROUND: Evidence is emerging that exposure to persistent organic pollutants (POP) is a risk factor for atherosclerosis-related diseases and for diabetes mellitus (DM). We hypothesized that residential proximity to sources of POP will be associated with an increase in hospitalization rates for ischemic stroke (IS) with comorbid DM (IS-DM). METHODS: We examined IS-DM hospitalization rates in the New York State (exclusive of New York City) during a 12-year period. POP exposure status was assessed based on residency in a zip code containing or abutting environmental sources of POP. Adjusted relative risks (RR) of IS-DM hospitalization were estimated by multivariate Poisson regression. RESULTS: A statistically significant 10% increase in IS-DM hospitalization rates was observed in populations environmentally exposed to POP (adjusted RR 1.10, 95% confidence interval, CI, 1.01-1.20; p = 0.031). IS-DM hospitalization rates were also higher in males (adjusted RR 1.34, 95% CI 1.30-1.39; p < 0.001), in blacks (adjusted RR 4.54, 95% CI 4.16-4.94; p < 0.001) and in older age groups (p for trend <0.001). CONCLUSIONS: Residential proximity to sources of POP is associated with an increase in RR of IS-DM hospitalization. Our findings support the hypothesis of POP being a risk factor for IS. Further studies are warranted.
Authors: Maria Kouznetsova; Xiaoyu Huang; Jing Ma; Lawrence Lessner; David O Carpenter Journal: Environ Health Perspect Date: 2007-01 Impact factor: 9.031
Authors: Partha Sarathi Mitra; Somiranjan Ghosh; Shizhu Zang; Dean Sonneborn; Irva Hertz-Picciotto; Tomas Trnovec; Lubica Palkovicova; Eva Sovcikova; Svetlana Ghimbovschi; Eric P Hoffman; Sisir K Dutta Journal: Environ Int Date: 2011-12-08 Impact factor: 9.621
Authors: Sisir K Dutta; Partha S Mitra; Somiranjan Ghosh; Shizhu Zang; Dean Sonneborn; Irva Hertz-Picciotto; Tomas Trnovec; Lubica Palkovicova; Eva Sovcikova; Svetlana Ghimbovschi; Eric P Hoffman Journal: Environ Int Date: 2011-09-08 Impact factor: 9.621