BACKGROUND: Among adolescents and young adults with DSM-IV alcohol use disorders (AUDs), there are inter-individual differences in the speed of transition from initial alcohol use (AU) to AUD. AUDs are highly co-morbid with other mental disorders. The factors associated with rapid transition from first AU to AUD remain unknown and the role of mental disorders in rapid transitions is unclear. Given this background we examined (1) whether prior anxiety, mood, externalizing and non-alcohol substance use disorders are related to the risk and speed of transition from first AU to DSM-IV alcohol abuse (AA) and alcohol dependence (AD) and (2) whether early age of onset of prior mental disorders (PMDs) is a promoter of rapid transition. METHOD: A total of 3021 community subjects (97.7% lifetime AU) aged 14-24 years at baseline were followed up prospectively for up to 10 years. AU and mental disorders were assessed with the DSM-IV/M-CIDI. RESULTS: Among subjects with lifetime AU, several PMDs, such as specific phobia, bipolar disorder and nicotine dependence, were associated with an increased risk of AUD independent of externalizing disorders. Associations of PMDs with the speed of transition to AUDs were mostly weak and inconsistent. Only social phobia and externalizing disorders were associated with faster transitions to AD even after adjustment for other PMDs. Earlier age of onset of PMD was not associated with rapid transition. CONCLUSIONS: Mental disorders are associated with the risk of AUD. With the possible exception of social phobia and externalizing disorders, they do not promote rapid transition, even if they occur particularly early. Future research needs to identify factors relevant to rapid transition to AUD.
BACKGROUND: Among adolescents and young adults with DSM-IV alcohol use disorders (AUDs), there are inter-individual differences in the speed of transition from initial alcohol use (AU) to AUD. AUDs are highly co-morbid with other mental disorders. The factors associated with rapid transition from first AU to AUD remain unknown and the role of mental disorders in rapid transitions is unclear. Given this background we examined (1) whether prior anxiety, mood, externalizing and non-alcohol substance use disorders are related to the risk and speed of transition from first AU to DSM-IV alcohol abuse (AA) and alcohol dependence (AD) and (2) whether early age of onset of prior mental disorders (PMDs) is a promoter of rapid transition. METHOD: A total of 3021 community subjects (97.7% lifetime AU) aged 14-24 years at baseline were followed up prospectively for up to 10 years. AU and mental disorders were assessed with the DSM-IV/M-CIDI. RESULTS: Among subjects with lifetime AU, several PMDs, such as specific phobia, bipolar disorder and nicotine dependence, were associated with an increased risk of AUD independent of externalizing disorders. Associations of PMDs with the speed of transition to AUDs were mostly weak and inconsistent. Only social phobia and externalizing disorders were associated with faster transitions to AD even after adjustment for other PMDs. Earlier age of onset of PMD was not associated with rapid transition. CONCLUSIONS:Mental disorders are associated with the risk of AUD. With the possible exception of social phobia and externalizing disorders, they do not promote rapid transition, even if they occur particularly early. Future research needs to identify factors relevant to rapid transition to AUD.
Authors: Jacob R Stephens; Jaimee L Heffner; Caleb M Adler; Thomas J Blom; Robert M Anthenelli; David E Fleck; Jeffrey A Welge; Stephen M Strakowski; Melissa P DelBello Journal: J Am Acad Child Adolesc Psychiatry Date: 2014-05-10 Impact factor: 8.829
Authors: S Patricia Chou; Hae K Lee; Maeng J Cho; Jong-Ik Park; Deborah A Dawson; Bridget F Grant Journal: Alcohol Clin Exp Res Date: 2011-09-15 Impact factor: 3.455
Authors: Benjamin I Goldstein; Michael Strober; David Axelson; Tina R Goldstein; Mary Kay Gill; Heather Hower; Daniel Dickstein; Jeffrey Hunt; Shirley Yen; Eunice Kim; Wonho Ha; Fangzi Liao; Jieyu Fan; Satish Iyengar; Neal D Ryan; Martin B Keller; Boris Birmaher Journal: J Am Acad Child Adolesc Psychiatry Date: 2013-07-31 Impact factor: 8.829
Authors: Rosa M Crum; Kerry M Green; Elizabeth A Stuart; Lareina N La Flair; Marc Kealhofer; Andrea S Young; Noa Krawczyk; Kayla N Tormohlen; Carla L Storr; Anika A H Alvanzo; Ramin Mojtabai; Lauren R Pacek; Bernadette A Cullen; Beth A Reboussin Journal: Drug Alcohol Depend Date: 2018-04-10 Impact factor: 4.492
Authors: Ludwing Flórez-Salamanca; Roberto Secades-Villa; Deborah S Hasin; Linda Cottler; Shuai Wang; Bridget F Grant; Carlos Blanco Journal: Am J Drug Alcohol Abuse Date: 2013-05 Impact factor: 3.829
Authors: Lindsey A Hines; Katherine I Morley; John Strang; Arpana Agrawal; Elliot C Nelson; Dixie Statham; Nicholas G Martin; Michael T Lynskey Journal: Drug Alcohol Depend Date: 2016-01-06 Impact factor: 4.492
Authors: Lauren R Pacek; Carla L Storr; Ramin Mojtabai; Kerry M Green; Lareina N La Flair; Anika A H Alvanzo; Bernadette A Cullen; Rosa M Crum Journal: J Dual Diagn Date: 2013