Literature DB >> 20661264

Brain disorders: getting 'Down' to the gene.

Lino Tessarollo.   

Abstract

Narrowing down the genetic basis of Down syndrome, in which hundreds of genes are triplicated, has been difficult. A new study finds that the expression of two affected genes, Olig1 and Olig2, is critical for maintaining the balance of inhibitory and excitatory signaling in a mouse model of Down syndrome.

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Year:  2010        PMID： 20661264     DOI： 10.1038/nn0810-909

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  13 in total

1.  Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

Authors:  Pavel V Belichenko; Eliezer Masliah; Alexander M Kleschevnikov; Angela J Villar; Charles J Epstein; Ahmad Salehi; William C Mobley
Journal:  J Comp Neurol       Date:  2004-12-13       Impact factor: 3.215

2.  Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

Authors:  Ahmad Salehi; Jean-Dominique Delcroix; Pavel V Belichenko; Ke Zhan; Chengbiao Wu; Janice S Valletta; Ryoko Takimoto-Kimura; Alexander M Kleschevnikov; Kumar Sambamurti; Peter P Chung; Weiming Xia; Angela Villar; William A Campbell; Laura Shapiro Kulnane; Ralph A Nixon; Bruce T Lamb; Charles J Epstein; Gorazd B Stokin; Lawrence S B Goldstein; William C Mobley
Journal:  Neuron       Date:  2006-07-06       Impact factor: 17.173

3.  Down syndrome and the genes of human chromosome 21: current knowledge and future potentials. Report on the Expert workshop on the biology of chromosome 21 genes: towards gene-phenotype correlations in Down syndrome. Washington D.C., September 28-October 1, 2007.

Authors:  M Pritchard; R H Reeves; M Dierssen; D Patterson; K J Gardiner
Journal:  Cytogenet Genome Res       Date:  2008-05-07       Impact factor: 1.636

4.  Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome.

Authors:  Sergey V Voronov; Samuel G Frere; Silvia Giovedi; Elizabeth A Pollina; Christelle Borel; Hong Zhang; Cecilia Schmidt; Ellen C Akeson; Markus R Wenk; Laurent Cimasoni; Ottavio Arancio; Muriel T Davisson; Stylianos E Antonarakis; Katheleen Gardiner; Pietro De Camilli; Gilbert Di Paolo
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-30       Impact factor: 11.205

5.  In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model.

Authors:  Susan G Dorsey; Cynthia L Renn; Laura Carim-Todd; Colleen A Barrick; Linda Bambrick; Bruce K Krueger; Christopher W Ward; Lino Tessarollo
Journal:  Neuron       Date:  2006-07-06       Impact factor: 17.173

6.  The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.

Authors:  Qiao Zhou; David J Anderson
Journal:  Cell       Date:  2002-04-05       Impact factor: 41.582

7.  Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

Authors:  Fabian Fernandez; Wade Morishita; Elizabeth Zuniga; James Nguyen; Martina Blank; Robert C Malenka; Craig C Garner
Journal:  Nat Neurosci       Date:  2007-02-25       Impact factor: 24.884

8.  Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

Authors:  Lina Chakrabarti; Zygmunt Galdzicki; Tarik F Haydar
Journal:  J Neurosci       Date:  2007-10-24       Impact factor: 6.167

9.  The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.

Authors:  Nadia P Belichenko; Pavel V Belichenko; Alexander M Kleschevnikov; Ahmad Salehi; Roger H Reeves; William C Mobley
Journal:  J Neurosci       Date:  2009-05-06       Impact factor: 6.167

Review 10.  Down syndrome--recent progress and future prospects.

Authors:  Frances K Wiseman; Kate A Alford; Victor L J Tybulewicz; Elizabeth M C Fisher
Journal:  Hum Mol Genet       Date:  2009-04-15       Impact factor: 6.150
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  1 in total

1.  Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome.

Authors:  Fabio M Simoes de Souza; Nicolas Busquet; Megan Blatner; Kenneth N Maclean; Diego Restrepo
Journal:  Sci Rep       Date:  2011-11-02       Impact factor: 4.379
  1 in total

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