Literature DB >> 2066114

Chromosomal assignment of a large tRNA gene cluster (tRNA(Leu), tRNA(Gln), tRNA(Lys), tRNA(Arg), tRNA(Gly)) to 17p13.1.

N Morrison1, J P Goddard, D H Ledbetter, E Boyd, D Bourn, J M Connor.   

Abstract

A cluster of tRNA genes (tRNA(UAGLeu), tRNA(CUGGln), tRNA(UUULys), tRNA(UCUArg)) and an adjacent tRNA(GCCGly) have been assigned to human chromosome 17p12-p13.1 by in situ hybridization using a 4.2 kb human DNA fragment for tRNA(Leu), tRNA(Gln), tRNA(Lys), tRNA(Arg), and, for tRNA(Gly), 1.3 kb and 0.58 kb human DNA fragments containing these genes as probes. This localization was confirmed and refined to 17p13.100-p13.105 using a somatic cell hybrid mapping panel. Preliminary experiments with the biotinylated tRNA Leu, Gln, Lys, Arg probe and metaphase spreads from other great apes suggest the presence of a hybridization site on the long arm of gorilla (Gorilla gorilla) chromosome 19 and the short arm of orangutan (Pongo pygmaeus) chromosome 19 providing further support for homology between HSA17, GGO19 and PPY19.

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Year:  1991        PMID： 2066114     DOI： 10.1007/BF00204190

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  18 in total

1.  Localization of three DNA segments encompassing tRNA genes to human chromosomes 1, 5, and 16: proposed mechanism and significance of tRNA gene dispersion.

Authors:  O W McBride; I L Pirtle; R M Pirtle
Journal:  Genomics       Date:  1989-10       Impact factor: 5.736

2.  Opal suppressor phosphoserine tRNA gene and pseudogene are located on human chromosomes 19 and 22, respectively.

Authors:  O W McBride; M Rajagopalan; D Hatfield
Journal:  J Biol Chem       Date:  1987-08-15       Impact factor: 5.157

3.  Nucleotide sequence and transcription of a human glycine tRNAGCC gene and nearby pseudogene.

Authors:  I L Pirtle; R D Shortridge; R M Pirtle
Journal:  Gene       Date:  1986       Impact factor: 3.688

4.  Proportion of HeLa cell genome complementary to transfer RNA and 5 s RNA.

Authors:  L Hatlen; G Attardi
Journal:  J Mol Biol       Date:  1971-03-28       Impact factor: 5.469

5.  Two human genes encoding tRNA(GCCGly).

Authors:  J L Doran; W H Bingle; K L Roy
Journal:  Gene       Date:  1988-05-30       Impact factor: 3.688

6.  Two nonallelic tRNAiMet genes are located in the p23 leads to q12 region of human chromosome 6.

Authors:  S L Naylor; A Y Sakaguchi; T B Shows; K H Grzeschik; M Holmes; M Zasloff
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

7.  Mutations in the p53 gene occur in diverse human tumour types.

Authors:  J M Nigro; S J Baker; A C Preisinger; J M Jessup; R Hostetter; K Cleary; S H Bigner; N Davidson; S Baylin; P Devilee
Journal:  Nature       Date:  1989-12-07       Impact factor: 49.962

8.  Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome.

Authors:  P vanTuinen; W B Dobyns; D C Rich; K M Summers; T J Robinson; Y Nakamura; D H Ledbetter
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

9.  Human U1 small nuclear RNA pseudogenes do not map to the site of the U1 genes in 1p36 but are clustered in 1q12-q22.

Authors:  V Lindgren; L B Bernstein; A M Weiner; U Francke
Journal:  Mol Cell Biol       Date:  1985-09       Impact factor: 4.272

10.  Regional mapping panel for human chromosome 17: application to neurofibromatosis type 1.

Authors:  P van Tuinen; D C Rich; K M Summers; D H Ledbetter
Journal:  Genomics       Date:  1987-12       Impact factor: 5.736
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