UNLABELLED: Our objective was to compare the predictive significance of (18)F-FDG PET/CT findings and circulating tumor cell (CTC) count in patients with bone metastases from breast cancer treated with standard systemic therapy. METHODS: Breast cancer patients with progressive bone-only metastatic disease without visceral metastases starting a new line of systemic therapy underwent (18)F-FDG PET/CT and had CTC counts determined before and during treatment. Disease status was reassessed by CTC count (> or = 5 vs. < 5 CTC/7.5 mL of blood) and (18)F-FDG PET/CT approximately 2-4 mo after initiation of the new systemic therapy. RESULTS: CTC counts at follow-up agreed with the (18)F-FDG PET/CT assessment in 43 (78%) of the 55 evaluable patients. Of the 12 patients with discordant CTC and (18)F-FDG PET/CT results, 8 (66%) had > or = 5 CTCs, with no evidence of progressive disease at the time of the (18)F-FDG PET/CT study, whereas 4 (33%) had < 5 CTCs, with evidence of progressive disease by (18)F-FDG PET/CT. (18)F-FDG PET/CT findings and follow-up CTC counts were found to be significantly associated with both progression-free survival (P = 0.02 and P < 0.0001, respectively) and overall survival (P = 0.02 and P = 0.01, respectively). In multivariate analysis, the (18)F-FDG PET/CT assessment remained as the only predictive factor for progression-free survival (P < 0.0001), whereas estrogen receptor status was the only predictive factor for overall survival (P = 0.01). CONCLUSION: (18)F-FDG PET/CT is a useful tool for therapeutic monitoring in patients with bone metastases from breast cancer. Prospective studies are needed to define the role of (18)F-FDG PET/CT and CTC in the setting of response discordance to establish bone-dominant disease as a tumor-response measurable disease.
UNLABELLED: Our objective was to compare the predictive significance of (18)F-FDG PET/CT findings and circulating tumor cell (CTC) count in patients with bone metastases from breast cancer treated with standard systemic therapy. METHODS:Breast cancerpatients with progressive bone-only metastatic disease without visceral metastases starting a new line of systemic therapy underwent (18)F-FDG PET/CT and had CTC counts determined before and during treatment. Disease status was reassessed by CTC count (> or = 5 vs. < 5 CTC/7.5 mL of blood) and (18)F-FDG PET/CT approximately 2-4 mo after initiation of the new systemic therapy. RESULTS: CTC counts at follow-up agreed with the (18)F-FDG PET/CT assessment in 43 (78%) of the 55 evaluable patients. Of the 12 patients with discordant CTC and (18)F-FDG PET/CT results, 8 (66%) had > or = 5 CTCs, with no evidence of progressive disease at the time of the (18)F-FDG PET/CT study, whereas 4 (33%) had < 5 CTCs, with evidence of progressive disease by (18)F-FDG PET/CT. (18)F-FDG PET/CT findings and follow-up CTC counts were found to be significantly associated with both progression-free survival (P = 0.02 and P < 0.0001, respectively) and overall survival (P = 0.02 and P = 0.01, respectively). In multivariate analysis, the (18)F-FDG PET/CT assessment remained as the only predictive factor for progression-free survival (P < 0.0001), whereas estrogen receptor status was the only predictive factor for overall survival (P = 0.01). CONCLUSION: (18)F-FDG PET/CT is a useful tool for therapeutic monitoring in patients with bone metastases from breast cancer. Prospective studies are needed to define the role of (18)F-FDG PET/CT and CTC in the setting of response discordance to establish bone-dominant disease as a tumor-response measurable disease.
Authors: F A Calvo; C V Sole; M E González; E D Tangco; J López-Tarjuelo; I Koubychine; J A Santos; J Pascau; R Herranz; C Ferrer Journal: Clin Transl Oncol Date: 2013-03-05 Impact factor: 3.405
Authors: F E Lecouvet; A Larbi; V Pasoglou; P Omoumi; B Tombal; N Michoux; J Malghem; R Lhommel; B C Vande Berg Journal: Eur Radiol Date: 2013-03-01 Impact factor: 5.315
Authors: Elizabeth M Jaffee; Chi Van Dang; David B Agus; Brian M Alexander; Kenneth C Anderson; Alan Ashworth; Anna D Barker; Roshan Bastani; Sangeeta Bhatia; Jeffrey A Bluestone; Otis Brawley; Atul J Butte; Daniel G Coit; Nancy E Davidson; Mark Davis; Ronald A DePinho; Robert B Diasio; Giulio Draetta; A Lindsay Frazier; Andrew Futreal; Sam S Gambhir; Patricia A Ganz; Levi Garraway; Stanton Gerson; Sumit Gupta; James Heath; Ruth I Hoffman; Cliff Hudis; Chanita Hughes-Halbert; Ramy Ibrahim; Hossein Jadvar; Brian Kavanagh; Rick Kittles; Quynh-Thu Le; Scott M Lippman; David Mankoff; Elaine R Mardis; Deborah K Mayer; Kelly McMasters; Neal J Meropol; Beverly Mitchell; Peter Naredi; Dean Ornish; Timothy M Pawlik; Jeffrey Peppercorn; Martin G Pomper; Derek Raghavan; Christine Ritchie; Sally W Schwarz; Richard Sullivan; Richard Wahl; Jedd D Wolchok; Sandra L Wong; Alfred Yung Journal: Lancet Oncol Date: 2017-10-31 Impact factor: 41.316
Authors: Andrew D Hughes; Jocelyn R Marshall; Eric Keller; John D Powderly; Bryan T Greene; Michael R King Journal: Cancer Lett Date: 2013-08-21 Impact factor: 8.679