Literature DB >> 20660134

Toxoplasma gondii cyclophilin 18 regulates the proliferation and migration of murine macrophages and spleen cells.

Hany M Ibrahim1, Xuenan Xuan, Yoshifumi Nishikawa.   

Abstract

Toxoplasma gondii is an intracellular parasite that shows a unique capacity to infect a variety of cell types in warm-blooded animals. It can invade and survive well inside immune cells, such as macrophages, that disseminate the parasite around the body because of their migratory properties. The aim of the present study was to evaluate the role of T. gondii cyclophilin 18 (TgCyp18) in the proliferation and migration of macrophages and spleen cells (mainly T lymphocytes) in order to understand the effects of TgCyp18 on the dynamics of the infection. A high dose of TgCyp18 enhanced the proliferation of macrophages and spleen cells in a cysteine-cysteine chemokine receptor 5 (CCR5)-independent way. In contrast, TgCyp18 controlled the migration of macrophages and spleen cells in dose- and CCR5-dependent manners. Our data suggest that TgCyp18 recruits cells and enhances the growth of host cells at the site of infection for maintenance of the interaction between the parasite and host.

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Year:  2010        PMID： 20660134      PMCID： PMC2944453          DOI： 10.1128/CVI.00128-10

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  43 in total

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Journal:  J Immunol       Date:  1999-06-15       Impact factor: 5.422

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Journal:  Clin Microbiol Rev       Date:  1998-10       Impact factor: 26.132

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Journal:  Trends Parasitol       Date:  2009-09-09

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Authors:  C Reis e Sousa; S Hieny; T Scharton-Kersten; D Jankovic; H Charest; R N Germain; A Sher
Journal:  J Exp Med       Date:  1997-12-01       Impact factor: 14.307

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Journal:  J Exp Med       Date:  1994-09-01       Impact factor: 14.307
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4.  Anti-neoplastic and immunomodulatory potency of co-treatment based on bovine lactoferrin and/or muramyl dipeptide in tumor-bearing mice.

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Review 5.  Passage of parasites across the blood-brain barrier.

Authors:  Willias Masocha; Krister Kristensson
Journal:  Virulence       Date:  2012-03-01       Impact factor: 5.882

6.  Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infections.

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7.  Imiquimod Targets Toxoplasmosis Through Modulating Host Toll-Like Receptor-MyD88 Signaling.

Authors:  Maguy Hamie; Rania Najm; Carine Deleuze-Masquefa; Pierre Antoine Bonnet; Jean-François Dubremetz; Marwan El Sabban; Hiba El Hajj
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8.  Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice.

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Journal:  Sci Rep       Date:  2022-07-12       Impact factor: 4.996

9.  Overproduction of Toxoplasma gondii cyclophilin-18 regulates host cell migration and enhances parasite dissemination in a CCR5-independent manner.

Authors:  Hany M Ibrahim; Maki Nishimura; Sachi Tanaka; Walaa Awadin; Hidefumi Furuoka; Xuenan Xuan; Yoshifumi Nishikawa
Journal:  BMC Microbiol       Date:  2014-03-25       Impact factor: 3.605

10.  Unravelling the Neospora caninum secretome through the secreted fraction (ESA) and quantification of the discharged tachyzoite using high-resolution mass spectrometry-based proteomics.

Authors:  Letícia Pollo-Oliveira; Harm Post; Marcio Luis Acencio; Ney Lemke; Henk van den Toorn; Vinicius Tragante; Albert J R Heck; A F Maarten Altelaar; Ana Patrícia Yatsuda
Journal:  Parasit Vectors       Date:  2013-11-23       Impact factor: 3.876
  10 in total

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