| Literature DB >> 20659804 |
Yoo Lim Kam1, Hee-Kyung Rhee, Hyewhon Rhim, Seung Keun Back, Heung Sik Na, Hea-Young Park Choo.
Abstract
Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20659804 DOI： 10.1016/j.bmc.2010.06.082
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641