Literature DB >> 20659800

Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery.

Thommey P Thomas1, Seok Ki Choi, Ming-Hsin Li, Alina Kotlyar, James R Baker.   

Abstract

This communication describes the synthesis and in vitro biological evaluation of novel generation 5 PAMAM dendrimers conjugated with riboflavin as a targeting ligand. Cell-based experiments demonstrated that a dendrimer conjugated with riboflavin is able to undergo cellular binding and uptake in KB cells, and when the dendrimer is also conjugated with methotrexate, the riboflavin dendrimer conjugate can potently inhibit cell growth. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20659800      PMCID： PMC2922453          DOI： 10.1016/j.bmcl.2010.07.005

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  31 in total

1.  Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate.

Authors:  Seok Ki Choi; Thommey Thomas; Ming-Hsin Li; Alina Kotlyar; Ankur Desai; James R Baker
Journal:  Chem Commun (Camb)       Date:  2010-02-06       Impact factor: 6.222

2.  Rational design of RGD-albumin conjugates for targeted delivery of the VEGF-R kinase inhibitor PTK787 to angiogenic endothelium.

Authors:  Kai Temming; Marie Lacombe; Roel Q J Schaapveld; László Orfi; Gyorgy Kéri; Klaas Poelstra; Grietje Molema; Robbert J Kok
Journal:  ChemMedChem       Date:  2006-11       Impact factor: 3.466

3.  Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications.

Authors:  R Esfand; D A. Tomalia
Journal:  Drug Discov Today       Date:  2001-04-01       Impact factor: 7.851

4.  Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.

Authors:  Jolanta F Kukowska-Latallo; Kimberly A Candido; Zhengyi Cao; Shraddha S Nigavekar; Istvan J Majoros; Thommey P Thomas; Lajos P Balogh; Mohamed K Khan; James R Baker
Journal:  Cancer Res       Date:  2005-06-15       Impact factor: 12.701

5.  Riboflavin carrier protein: a serum and tissue marker for breast carcinoma.

Authors:  A A Karande; L Sridhar; K S Gopinath; P R Adiga
Journal:  Int J Cancer       Date:  2001-09-20       Impact factor: 7.396

6.  Targeting and inhibition of cell growth by an engineered dendritic nanodevice.

Authors:  Thommey P Thomas; Istvan J Majoros; Alina Kotlyar; Jolanta F Kukowska-Latallo; Anna Bielinska; Andrzej Myc; James R Baker
Journal:  J Med Chem       Date:  2005-06-02       Impact factor: 7.446

7.  Riboflavin-mediated delivery of a macromolecule into cultured human cells.

Authors:  S R Holladay; Z Yang; M D Kennedy; C P Leamon; R J Lee; M Jayamani; T Mason; P S Low
Journal:  Biochim Biophys Acta       Date:  1999-01-04

8.  PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality.

Authors:  István J Majoros; Andrzej Myc; Thommey Thomas; Chandan B Mehta; James R Baker
Journal:  Biomacromolecules       Date:  2006-02       Impact factor: 6.988

9.  Targeted gene delivery mediated by folate-polyethylenimine-block-poly(ethylene glycol) with receptor selectivity.

Authors:  Han Cheng; Jing-Ling Zhu; Xuan Zeng; Yue Jing; Xian-Zheng Zhang; Ren-Xi Zhuo
Journal:  Bioconjug Chem       Date:  2009-03-18       Impact factor: 4.774

10.  Biochemical characterization of riboflavin carrier protein (RCP) in prostate cancer.

Authors:  Tanya Johnson; Allal Ouhtit; Rajiv Gaur; Augusta Fernando; Paul Schwarzenberger; Joseph Su; Mohamed F Ismail; Hassan I El-Sayyad; Anjali Karande; Zakaria Abd Elmageed; Prakash Rao; Madhwa Raj
Journal:  Front Biosci (Landmark Ed)       Date:  2009-01-01
View more
  16 in total

1.  Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targeting.

Authors:  Ming-Hsin Li; Seok Ki Choi; Thommey P Thomas; Ankur Desai; Kyung-Hoon Lee; Alina Kotlyar; Mark M Banaszak Holl; James R Baker
Journal:  Eur J Med Chem       Date:  2011-11-23       Impact factor: 6.514

2.  Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic.

Authors:  Thommey P Thomas; Baohua Huang; Seok Ki Choi; Justin E Silpe; Alina Kotlyar; Ankur M Desai; Hong Zong; Jeremy Gam; Melvin Joice; James R Baker
Journal:  Mol Pharm       Date:  2012-08-07       Impact factor: 4.939

3.  Design and in vitro validation of multivalent dendrimer methotrexates as a folate-targeting anticancer therapeutic.

Authors:  Thommey P Thomas; Melvin Joice; Madhuresh Sumit; Justin E Silpe; Alina Kotlyar; Sophia Bharathi; Jolanta Kukowska-Latallo; James R Baker; Seok Ki Choi
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

4.  Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery - A Thermodynamic and Kinetic Study.

Authors:  Anna Plantinga; Amanda Witte; Ming-Hsin Li; Andrew Harmon; Seok Ki Choi; Mark M Banaszak Holl; Bradford G Orr; James R Baker; Kumar Sinniah
Journal:  ACS Med Chem Lett       Date:  2011-05-12       Impact factor: 4.345

5.  Biophysical characterization of a riboflavin-conjugated dendrimer platform for targeted drug delivery.

Authors:  Amanda B Witte; Christine M Timmer; Jeremy J Gam; Seok Ki Choi; Mark M Banaszak Holl; Bradford G Orr; James R Baker; Kumar Sinniah
Journal:  Biomacromolecules       Date:  2012-01-18       Impact factor: 6.988

6.  Avidity modulation of folate-targeted multivalent dendrimers for evaluating biophysical models of cancer targeting nanoparticles.

Authors:  Justin E Silpe; Madhuresh Sumit; Thommey P Thomas; Baohua Huang; Alina Kotlyar; Mallory A van Dongen; Mark M Banaszak Holl; Bradford G Orr; Seok Ki Choi
Journal:  ACS Chem Biol       Date:  2013-07-26       Impact factor: 5.100

7.  Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate.

Authors:  Seok Ki Choi; Thommey P Thomas; Ming-Hsin Li; Ankur Desai; Alina Kotlyar; James R Baker
Journal:  Photochem Photobiol Sci       Date:  2012-01-11       Impact factor: 3.982

8.  A photochemical approach for controlled drug release in targeted drug delivery.

Authors:  Seok Ki Choi; Manisha Verma; Justin Silpe; Ryan E Moody; Kenny Tang; Jeffrey J Hanson; James R Baker
Journal:  Bioorg Med Chem       Date:  2011-12-20       Impact factor: 3.641

9.  Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate.

Authors:  A Filipowicz; S Wołowiec
Journal:  Int J Nanomedicine       Date:  2012-09-06

10.  Atomic force microscopy probing of receptor-nanoparticle interactions for riboflavin receptor targeted gold-dendrimer nanocomposites.

Authors:  Amanda B Witte; Abigail N Leistra; Pamela T Wong; Sophia Bharathi; Kevin Refior; Phillip Smith; Ola Kaso; Kumar Sinniah; Seok Ki Choi
Journal:  J Phys Chem B       Date:  2014-03-07       Impact factor: 2.991
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.