Bioactive cell-penetrating peptides: kill two birds with one stone.

Jones et al. (2010) propose an innovative strategy for the development of bioactive cell-penetrating peptides. They combine computer-based design with specific targeting to elaborate a potent cell-penetrating bioactive peptide derived from cytochrome C. This short chimera peptide induces tumor cell apoptosis by targeting and sequestering nucleoporin, a key component of the nuclear pore complex. 2010 Elsevier Ltd. All rights reserved.