Literature DB >> 20657415

Synthesis and adrenolytic activity of new propanolamines.

Grazyna Groszek1, Agata Bajek, Agnieszka Bis, Agnieszka Nowak-Król, Marek Bednarski, Agata Siwek, Barbara Filipek.   

Abstract

The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for alpha(1)-, alpha(2)- and beta(1)-adrenoceptor binding affinity.

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Year:  2010        PMID： 20657415      PMCID： PMC6264682          DOI： 10.3390/molecules15063887

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  22 in total

1.  SOME CARDIOVASCULAR EFFECTS OF A SERIES OF ARYLOXYALKYLAMINES. I.

Authors:  J AUGSTEIN; W C AUSTIN; R J BOSCOTT; S M GREEN; C R WORTHING
Journal:  J Med Chem       Date:  1965-05       Impact factor: 7.446

Review 2.  Effect of alpha1-adrenergic receptors in cardiac pathophysiology.

Authors:  Richard Shannon; Mohammad Chaudhry
Journal:  Am Heart J       Date:  2006-11       Impact factor: 4.749

3.  Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2.

Authors:  Grazyna Groszek; Agnieszka Nowak-Król; Tomasz Wdowik; Dariusz Swierczyński; Marek Bednarski; Monika Otto; Maria Walczak; Barbara Filipek
Journal:  Eur J Med Chem       Date:  2009-07-21       Impact factor: 6.514

4.  Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol and its enantiomers. Part 1.

Authors:  Grazyna Groszek; Marek Bednarski; Małgorzata Dybała; Barbara Filipek
Journal:  Eur J Med Chem       Date:  2008-07-02       Impact factor: 6.514

Review 5.  A list of vertebrate cardiac ionic currents nomenclature, properties, function and cloned equivalents.

Authors:  M R Boyett; S M Harrison; N C Janvier; S O McMorn; J M Owen; Z Shui
Journal:  Cardiovasc Res       Date:  1996-09       Impact factor: 10.787

6.  Differential effects of bucindolol and carvedilol on noradenaline-induced hypertrophic response in ventricular cardiomyocytes of adult rats.

Authors:  Klaus Pönicke; Ingrid Heinroth-Hoffmann; Otto-Erich Brodde
Journal:  J Pharmacol Exp Ther       Date:  2002-04       Impact factor: 4.030

7.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors:  Y Cheng; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858

8.  Antioxidative bromoindole derivatives from the mid-intestinal gland of the muricid gastropod Drupella fragum.

Authors:  M Ochi; K Kataoka; S Ariki; C Iwatsuki; M Kodama; Y Fukuyama
Journal:  J Nat Prod       Date:  1998-08       Impact factor: 4.050

9.  Propranolol analogs containing natural monoterpene structures: synthesis and pharmacological properties.

Authors:  A Siemieniuk; H Szałkowska-Pagowska; S Lochyński; K Piatkowski; B Filipek; J Krupińska; R Czarnecki; T Librowski; S Białas
Journal:  Pol J Pharmacol Pharm       Date:  1992 Nov-Dec

10.  The effect of adrenergic receptor antagonists on cocaine-induced ventricular fibrillation: alpha but not beta adrenergic receptor antagonists prevent malignant arrhythmias independent of heart rate.

Authors:  G E Billman
Journal:  J Pharmacol Exp Ther       Date:  1994-04       Impact factor: 4.030
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