| Literature DB >> 20656083 |
Francesca Mandanici1, Lidia Gómez-Gascón, Manuela Garibaldi, Alfonso Olaya-Abril, Inmaculada Luque, Carmen Tarradas, Giuseppe Mancuso, Salvatore Papasergi, J Antonio Bárcena, Giuseppe Teti, Concetta Beninati, Manuel J Rodríguez-Ortega.
Abstract
Streptococcus suis serotype 2 is a major Gram-positive swine pathogen, causing also zoonoses. We describe here the immunoprotective activity in an in vivo animal model of a serotype-2 cell wall protein, designated Sat, which was identified by a previously validated proteomics approach consisting of the protease digestion of live bacteria and the selective recovery of exposed domains, followed by LC/MS/MS analysis. Increased survival rate (80%) and decreased bacterial burden were observed in mice immunized with a recombinant Sat fragment, suggesting that this protein is a potential vaccine candidate against serotype-2 infection.Entities:
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Year: 2010 PMID： 20656083 DOI： 10.1016/j.jprot.2010.07.009
Source DB: PubMed Journal: J Proteomics ISSN： 1874-3919 Impact factor: 4.044