Literature DB >> 20655982

Vasoactive intestinal peptide (VIP)-mediated expression and function of steroidogenic acute regulatory protein (StAR) in granulosa cells.

Mariusz P Kowalewski1, Matthew T Dyson, Alois Boos, Douglas M Stocco.   

Abstract

VIP is a peptide hormone capable of activating the cAMP/PKA pathway and modifying gonadal steroidogenic capacity. Less is known about the molecular mechanisms of VIP-mediated steroidogenesis and its role in regulating the steroidogenic acute regulatory protein (STAR). We examined the impact of VIP on STAR expression and function in immortalized (KK1) and primary mouse granulosa cells, where VIP strongly upregulated STAR expression and steroidogenesis. Inhibitors of the PKA and PKC pathways suggested that both are activated by VIP. VIP did not efficiently phosphorylate STAR (P-STAR); however, VIP together with cAMP-analogs that activate Type II PKA increased P-STAR and further increased steroidogenesis. Our results suggest that VIP-induced STAR expression and function in granulosa cells result from the preferential activation of Type I PKA. Furthermore, the PKA and PKC pathways appear to converge at regulating VIP-mediated Star transcription and translation. Published by Elsevier Ireland Ltd.

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Year:  2010        PMID： 20655982      PMCID： PMC5010784          DOI： 10.1016/j.mce.2010.07.018

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  34 in total

1.  The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule.

Authors:  H S Bose; R M Whittal; M A Baldwin; W L Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

2.  Vasoactive intestinal peptide stimulates testosterone production by cultured fetal rat testicular cells.

Authors:  F El-Gehani; M Tena-Sempere; I Huhtaniemi
Journal:  Mol Cell Endocrinol       Date:  1998-05-25       Impact factor: 4.102

3.  Characterization and expression of different pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptors in rat ovarian follicles.

Authors:  Sergio Vaccari; Stefania Latini; Marzia Barberi; Anna Teti; Mario Stefanini; Rita Canipari
Journal:  J Endocrinol       Date:  2006-10       Impact factor: 4.286

4.  Abdominal vagotomy delays the onset of puberty and inhibits ovarian function in the female rat.

Authors:  S R Ojeda; S S White; L I Aguado; J P Advis; J M Andersen
Journal:  Neuroendocrinology       Date:  1983       Impact factor: 4.914

5.  Neonatal superior ovarian nerve transection disturbs the cyclic activity of the female rats.

Authors:  Myriam L Forneris; Luis I Aguado
Journal:  J Steroid Biochem Mol Biol       Date:  2002-09       Impact factor: 4.292

6.  Immunocytochemical localization of vasoactive intestinal peptide and neuropeptide Y in the bovine ovary.

Authors:  S C Hulshof; G Dijkstra; E M Van der Beek; M M Bevers; J R Figueiredo; J F Beckers; R Van den Hurk
Journal:  Biol Reprod       Date:  1994-03       Impact factor: 4.285

7.  Lack of vasoactive intestinal peptide reduces testosterone levels and reproductive aging in mouse testis.

Authors:  Arnaud Lacombe; Vincent Lelievre; Charles E Roselli; Jean-Marc Muller; James A Waschek; Eric Vilain
Journal:  J Endocrinol       Date:  2007-07       Impact factor: 4.286

8.  Origin and distribution of VIP (vasoactive intestinal polypeptide)-nerves in the genito-urinary tract.

Authors:  P Alm; J Alumets; R Håkanson; O Owman; N O Sjöberg; F Sundler; B Walles
Journal:  Cell Tissue Res       Date:  1980       Impact factor: 5.249

9.  Vasoactive intestinal peptide: a novel stimulator of steroidogenesis by cultured rat granulosa cells.

Authors:  J B Davoren; A J Hsueh
Journal:  Biol Reprod       Date:  1985-08       Impact factor: 4.285

10.  Guanethidine-mediated destruction of ovarian sympathetic nerves disrupts ovarian development and function in rats.

Authors:  H E Lara; J K McDonald; C E Ahmed; S R Ojeda
Journal:  Endocrinology       Date:  1990-11       Impact factor: 4.736
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  5 in total

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Authors:  D H Loh; D A Kuljis; L Azuma; Y Wu; D Truong; H B Wang; C S Colwell
Journal:  J Biol Rhythms       Date:  2014-09-24       Impact factor: 3.182

2.  Asymmetric steroidogenic response by the ovaries to the vasoactive intestinal peptide.

Authors:  Gabriela Rosas; María Isabel Ramírez; Rosa Linares; Angélica Trujillo; Roberto Domínguez; Leticia Morales-Ledesma
Journal:  Endocrine       Date:  2014-10-21       Impact factor: 3.633

3.  Absence of the long noncoding RNA H19 results in aberrant ovarian STAR and progesterone production.

Authors:  Yong Chen; Jing Wang; Yanhong Fan; Chunrong Qin; Xi Xia; Joshua Johnson; Amanda N Kallen
Journal:  Mol Cell Endocrinol       Date:  2019-03-25       Impact factor: 4.102

4.  The Neural Signals of the Superior Ovarian Nerve Modulate in an Asymmetric Way the Ovarian Steroidogenic Response to the Vasoactive Intestinal Peptide.

Authors:  Gabriela Rosas; Rosa Linares; Deyra A Ramírez; Elizabeth Vieyra; Angélica Trujillo; Roberto Domínguez; Leticia Morales-Ledesma
Journal:  Front Physiol       Date:  2018-08-20       Impact factor: 4.566

5.  Molecular Mechanisms of Lipopolysaccharide (LPS) Induced Inflammation in an Immortalized Ovine Luteal Endothelial Cell Line (OLENDO).

Authors:  Aykut Gram; Mariusz P Kowalewski
Journal:  Vet Sci       Date:  2022-02-24
  5 in total

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