| Literature DB >> 20655790 |
O Mercereau-Puijalon1, D Ménard.
Abstract
The Duffy blood group antigen is the portal of entry of the Plasmodiumvivax malaria parasite into human red blood cells and the receptor for a number of CXC and CC chemokines. We review here epidemiological data and evidence derived from therapeutic or experimental human infections associating P. vivax and the Duffy glycoprotein and laboratory studies indicating that P. vivax uses the Duffy antigen as a receptor to invade the red cell. We then review recent field observations indicating that the conclusion of the absolute dependence on the presence of Duffy on the red cell for P. vivax infection and development into the red cell no longer holds true and that in some parts of the world, P. vivax infects and causes disease in Duffy-negative people. Copyright 2010 Elsevier Masson SAS. All rights reserved.Entities:
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Year: 2010 PMID： 20655790 DOI： 10.1016/j.tracli.2010.06.005
Source DB: PubMed Journal: Transfus Clin Biol ISSN： 1246-7820 Impact factor: 1.406