Literature DB >> 20655311

Galectin-3 secreted by human umbilical cord blood-derived mesenchymal stem cells reduces amyloid-beta42 neurotoxicity in vitro.

Ju-Yeon Kim1, Dong Hyun Kim, Dal-Soo Kim, Ji Hyun Kim, Sang Young Jeong, Hong Bae Jeon, Eun Hui Lee, Yoon Sun Yang, Wonil Oh, Jong Wook Chang.   

Abstract

In this study, we found that expression and secretion of galectin-3 (GAL-3) were upregulated by amyloid-beta42 (Abeta42) exposure in human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) without cell death. Abeta42-exposed rat primary cortical neuronal cells co-treated with recombinant GAL-3 were protected from neuronal death in a dose-dependent manner. hUCB-MSCs were cocultured with Abeta42-exposed rat primary neuronal cells or the neuroblastoma cell line, SH-SY5Y in a Transwell chamber. Coculture of hUCB-MSCs reduced cell death of Abeta42-exposed neurons and SH-SY5Y cells. This neuroprotective effect of hUCB-MSCs was reduced significantly by GAL-3 siRNA. These data suggested that hUCB-MSC-derived GAL-3 is a survival factor against Abeta42 neurotoxicity. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20655311     DOI： 10.1016/j.febslet.2010.07.028

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  25 in total

1.  Anti-apoptotic Effects of Human Wharton's Jelly-derived Mesenchymal Stem Cells on Skeletal Muscle Cells Mediated via Secretion of XCL1.

Authors:  SooJin Kwon; Soo Mi Ki; Sang Eon Park; Min-Jeong Kim; Brian Hyung; Na Kyung Lee; Sangmi Shim; Byung-Ok Choi; Duk L Na; Ji Eun Lee; Jong Wook Chang
Journal:  Mol Ther       Date:  2016-06-23       Impact factor: 11.454

2.  GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer's disease model.

Authors:  Dong Hyun Kim; Dahm Lee; Eun Hyuk Chang; Ji Hyun Kim; Jung Won Hwang; Ju-Yeon Kim; Jae Won Kyung; Sung Hyun Kim; Jeong Su Oh; Sang Mi Shim; Duk Lyul Na; Wonil Oh; Jong Wook Chang
Journal:  Stem Cells Dev       Date:  2015-08-19       Impact factor: 3.272

3.  GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies.

Authors:  Evelyn Pardo; Francisca Barake; Juan A Godoy; Claudia Oyanadel; Sofía Espinoza; Claudia Metz; Claudio Retamal; Loreto Massardo; Cheril Tapia-Rojas; Nibaldo C Inestrosa; Andrea Soza; Alfonso González
Journal:  Mol Neurobiol       Date:  2019-05-22       Impact factor: 5.590

4.  Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

Authors:  Mariana A de Godoy; Leonardo M Saraiva; Luiza R P de Carvalho; Andreia Vasconcelos-Dos-Santos; Hellen J V Beiral; Alane Bernardo Ramos; Livian R de Paula Silva; Renata B Leal; Victor H S Monteiro; Carolina V Braga; Carlla A de Araujo-Silva; Leandro C Sinis; Victor Bodart-Santos; Tais Hanae Kasai-Brunswick; Carolina de Lima Alcantara; Ana Paula C A Lima; Narcisa L da Cunha-E Silva; Antonio Galina; Adalberto Vieyra; Fernanda G De Felice; Rosalia Mendez-Otero; Sergio T Ferreira
Journal:  J Biol Chem       Date:  2017-12-28       Impact factor: 5.157

5.  Umbilical cord blood mesenchymal stem cells protect amyloid-β42 neurotoxicity via paracrine.

Authors:  Ju-Yeon Kim; Dong Hyun Kim; Ji Hyun Kim; Yoon Sun Yang; Wonil Oh; Eun Hui Lee; Jong Wook Chang
Journal:  World J Stem Cells       Date:  2012-11-26       Impact factor: 5.326

6.  Downregulation of Melanoma Cell Adhesion Molecule (MCAM/CD146) Accelerates Cellular Senescence in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells.

Authors:  Hye Jin Jin; Ji Hye Kwon; Miyeon Kim; Yun Kyung Bae; Soo Jin Choi; Wonil Oh; Yoon Sun Yang; Hong Bae Jeon
Journal:  Stem Cells Transl Med       Date:  2016-03-03       Impact factor: 6.940

7.  Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models.

Authors:  Jin Young Shin; Hyun Jung Park; Ha Na Kim; Se Hee Oh; Jae-Sung Bae; Hee-Jin Ha; Phil Hyu Lee
Journal:  Autophagy       Date:  2013-01-01       Impact factor: 16.016

8.  Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy.

Authors:  Hye Jin Jin; Yun Kyung Bae; Miyeon Kim; Soon-Jae Kwon; Hong Bae Jeon; Soo Jin Choi; Seong Who Kim; Yoon Sun Yang; Wonil Oh; Jong Wook Chang
Journal:  Int J Mol Sci       Date:  2013-09-03       Impact factor: 5.923

9.  Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques.

Authors:  J-Y Kim; D H Kim; J H Kim; D Lee; H B Jeon; S-J Kwon; S M Kim; Y J Yoo; E H Lee; S J Choi; S W Seo; J I Lee; D L Na; Y S Yang; W Oh; J W Chang
Journal:  Cell Death Differ       Date:  2011-10-21       Impact factor: 15.828

Review 10.  Microglia in Alzheimer's Disease: The Role of Stem Cell-Microglia Interaction in Brain Homeostasis.

Authors:  Saeid Bagheri-Mohammadi
Journal:  Neurochem Res       Date:  2020-11-10       Impact factor: 3.996
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