Literature DB >> 20655219

Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.

James McNulty1, Jerald J Nair, Jessamyn R L Little, John D Brennan, Jaume Bastida.   

Abstract

The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series. Important elements of this novel pharmacophore were elucidated through structure-activity relationship (SAR) studies. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20655219     DOI： 10.1016/j.bmcl.2010.06.130

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

Review 1.  The role of phytochemicals in the treatment and prevention of dementia.

Authors:  Melanie-Jayne R Howes; Elaine Perry
Journal:  Drugs Aging       Date:  2011-06-01       Impact factor: 3.923

2.  Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation.

Authors:  Sergey Vshyvenko; Jon Scattolon; Tomas Hudlicky; Anntherese E Romero; Alexander Kornienko
Journal:  Bioorg Med Chem Lett       Date:  2011-06-22       Impact factor: 2.823

3.  In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives.

Authors:  Nikolai M Evdokimov; Delphine Lamoral-Theys; Véronique Mathieu; Anna Andolfi; Liliya V Frolova; Stephen C Pelly; Willem A L van Otterlo; Igor V Magedov; Robert Kiss; Antonio Evidente; Alexander Kornienko
Journal:  Bioorg Med Chem       Date:  2011-10-02       Impact factor: 3.641

4.  Unnatural C-1 homologues of pancratistatin - Synthesis and promising biological activities.

Authors:  Sergey Vshyvenko; Jon Scattolon; Tomas Hudlicky; Anntherese E Romero; Alexander Kornienko; Dennis Ma; Ian Tuffley; Siyaram Pandey
Journal:  Can J Chem       Date:  2012-09-19       Impact factor: 1.118

5.  GC/MS Analysis of Alkaloids in Galanthus fosteri Baker and Determination of Its Anticholinesterase Activity.

Authors:  Ahmet Emir; Ceren Emir; Buket Bozkurt; Nehir Ünver Somer
Journal:  Turk J Pharm Sci       Date:  2020-02-19

6.  The influences of four types of soil on the growth, physiological and biochemical characteristics of Lycoris aurea (L' Her.) Herb.

Authors:  Miaohua Quan; Juan Liang
Journal:  Sci Rep       Date:  2017-02-27       Impact factor: 4.379

7.  Asymmetric Entry into 10b-aza-Analogues of Amaryllidaceae Alkaloids Reveals a Pronounced Electronic Effect on Antiviral Activity.

Authors:  Carla E Brown; Tiffany Kong; James F Britten; Nick H Werstiuk; James McNulty; Leonardo D'Aiuto; Matthew Demers; Vishwajit L Nimgaonkar
Journal:  ACS Omega       Date:  2018-09-20

Review 8.  Lycorine: A prospective natural lead for anticancer drug discovery.

Authors:  Mridul Roy; Long Liang; Xiaojuan Xiao; Peifu Feng; Mao Ye; Jing Liu
Journal:  Biomed Pharmacother       Date:  2018-08-14       Impact factor: 6.529

9.  Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase.

Authors:  Yue-Hu Wang; Qin-Li Wan; Cheng-Ding Gu; Huai-Rong Luo; Chun-Lin Long
Journal:  Chem Cent J       Date:  2012-09-08       Impact factor: 4.215

10.  Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives.

Authors:  Peng Wang; Lin-Feng Li; Qing-Yin Wang; Lu-Qing Shang; Pei-Yong Shi; Zheng Yin
Journal:  ChemMedChem       Date:  2014-02-26       Impact factor: 3.466
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