Literature DB >> 20654690

Melanocortin receptors and their accessory proteins.

Sadani N Cooray1, Adrian J L Clark.   

Abstract

The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for their function. Like these GPCRs the melanocortin receptor family is also known to be associated with accessory proteins that regulate their function. In this review we will summarise the accessory proteins involved in the function of the 5 melanocortin receptors and in particular focus on the melanocortin 2 receptor accessory protein (MRAP) which is crucial for the function of the MC2R.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

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Year:  2010        PMID： 20654690     DOI： 10.1016/j.mce.2010.07.015

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  20 in total

Review 1.  Intracellular signaling mechanisms of the melanocortin receptors: current state of the art.

Authors:  Adriana R Rodrigues; Henrique Almeida; Alexandra M Gouveia
Journal:  Cell Mol Life Sci       Date:  2014-12-12       Impact factor: 9.261

2.  Pubertal shifts in adrenal responsiveness to stress and adrenocorticotropic hormone in male rats.

Authors:  Russell D Romeo; Sumeet Minhas; Sarah E Svirsky; Baila S Hall; Marina Savenkova; Ilia N Karatsoreos
Journal:  Psychoneuroendocrinology       Date:  2014-01-30       Impact factor: 4.905

3.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

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Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

4.  Mechanisms of melanocortin-2 receptor (MC2R) internalization and recycling in human embryonic kidney (hek) cells: identification of Key Ser/Thr (S/T) amino acids.

Authors:  Simon Roy; Sébastien Jean Roy; Sandra Pinard; Louis-Daniel Taillefer; Mohamed Rached; Jean-Luc Parent; Nicole Gallo-Payet
Journal:  Mol Endocrinol       Date:  2011-09-15

Review 5.  Adolescence and the ontogeny of the hormonal stress response in male and female rats and mice.

Authors:  Russell D Romeo; Ravenna Patel; Laurie Pham; Veronica M So
Journal:  Neurosci Biobehav Rev       Date:  2016-05-24       Impact factor: 8.989

6.  Estrogen Suppresses Interaction of Melanocortin 2 Receptor and Its Accessory Protein in the Primate Fetal Adrenal Cortex.

Authors:  Jeffery S Babischkin; Graham W Aberdeen; Gerald J Pepe; Eugene D Albrecht
Journal:  Endocrinology       Date:  2016-10-25       Impact factor: 4.736

7.  Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice.

Authors:  Darren J Lee; Andrew W Taylor
Journal:  J Immunol       Date:  2013-09-16       Impact factor: 5.422

8.  Molecular cloning and expression analysis of mc5r like genes (mc5rl) in Ruditapes philippinarum (Manila clam) after aerial exposure and low-temperature stress.

Authors:  Kunyin Jiang; Hongtao Nie; Xiwu Yan
Journal:  Mol Biol Rep       Date:  2020-10-31       Impact factor: 2.316

9.  Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors.

Authors:  Minying Cai; Udaya Kiran Marelli; Jennifer Bao; Johannes G Beck; Florian Opperer; Florian Rechenmacher; Kaitlyn R McLeod; Morgan R Zingsheim; Lucas Doedens; Horst Kessler; Victor J Hruby
Journal:  J Med Chem       Date:  2015-08-11       Impact factor: 7.446

10.  Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.

Authors:  Masato Asai; Shwetha Ramachandrappa; Maria Joachim; Yuan Shen; Rong Zhang; Nikhil Nuthalapati; Visali Ramanathan; David E Strochlic; Peter Ferket; Kirsten Linhart; Caroline Ho; Tatiana V Novoselova; Sumedha Garg; Martin Ridderstråle; Claude Marcus; Joel N Hirschhorn; Julia M Keogh; Stephen O'Rahilly; Li F Chan; Adrian J Clark; I Sadaf Farooqi; Joseph A Majzoub
Journal:  Science       Date:  2013-07-19       Impact factor: 47.728
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