Literature DB >> 20653444

DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection.

Pushpinder Kaur1, Anupam Paliwal, David Durantel, Pierre Hainaut, Jean-Yves Scoazec, Fabien Zoulim, Isabelle Chemin, Zdenko Herceg.   

Abstract

Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and have suggested that it may be an important mechanism regulating transcription and replication of the HBV virus. However, it remains unclear whether this phenomenon is associated with occult hepatitis. Here, we performed a detailed analysis of DNA methylation in the HBV genome in liver samples of patients at different stages of hepatocarcinoma development and in in vitro infected hepatocytes and found discrete CpG sites in the HBV genome that are recurrently hypermethylated in cancer but not in chronic hepatitis tissue.

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Year:  2010        PMID： 20653444     DOI： 10.1086/655398

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  29 in total

Review 1.  Genetic variation of occult hepatitis B virus infection.

Authors:  Hui-Lan Zhu; Xu Li; Jun Li; Zhen-Hua Zhang
Journal:  World J Gastroenterol       Date:  2016-04-07       Impact factor: 5.742

Review 2.  Occult hepatitis B virus infection and blood transfusion.

Authors:  Dong Hee Seo; Dong Hee Whang; Eun Young Song; Kyou Sup Han
Journal:  World J Hepatol       Date:  2015-03-27

3.  Promoter hypermethylation of p14 (ARF) , RB, and INK4 gene family in hepatocellular carcinoma with hepatitis B virus infection.

Authors:  Ji-Cai Zhang; Bo Gao; Zong-Tao Yu; Xiao-Bo Liu; Jun Lu; Fei Xie; Hai-Jun Luo; Hai-Ping Li
Journal:  Tumour Biol       Date:  2013-11-20

Review 4.  Molecular mechanisms underlying occult hepatitis B virus infection.

Authors:  Jasmine Samal; Manish Kandpal; Perumal Vivekanandan
Journal:  Clin Microbiol Rev       Date:  2012-01       Impact factor: 26.132

Review 5.  Occult hepatitis B virus infection.

Authors:  Min-Sun Kwak; Yoon Jun Kim
Journal:  World J Hepatol       Date:  2014-12-27

Review 6.  Detection of cancer-specific epigenomic changes in biofluids: powerful tools in biomarker discovery and application.

Authors:  André Nogueira da Costa; Zdenko Herceg
Journal:  Mol Oncol       Date:  2012-08-16       Impact factor: 6.603

Review 7.  Occult hepatitis B virus and hepatocellular carcinoma.

Authors:  Teresa Pollicino; Carlo Saitta
Journal:  World J Gastroenterol       Date:  2014-05-28       Impact factor: 5.742

8.  Mutations associated with occult hepatitis B in HIV-positive South Africans.

Authors:  Eleanor A Powell; Maemu P Gededzha; Michael Rentz; Nare J Rakgole; Selokela G Selabe; Tebogo A Seleise; M Jeffrey Mphahlele; Jason T Blackard
Journal:  J Med Virol       Date:  2014-08-27       Impact factor: 2.327

9.  Influence of age and HBeAg status on the correlation between HBV DNA and hepatic inflammation and fibrosis in chronic hepatitis B patients.

Authors:  Han Bai; Hongbo Liu; Xiaokai Chen; Chan Xu; Xiaoguang Dou
Journal:  Dig Dis Sci       Date:  2012-11-22       Impact factor: 3.199

Review 10.  Virological Basis for the Cure of Chronic Hepatitis B.

Authors:  Jin Hu; Junjun Cheng; Liudi Tang; Zhanying Hu; Yue Luo; Yuhuan Li; Tianlun Zhou; Jinhong Chang; Ju-Tao Guo
Journal:  ACS Infect Dis       Date:  2018-06-25       Impact factor: 5.084
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