Literature DB >> 20652839

Legacy effects from DCCT and UKPDS: what they mean and implications for future diabetes trials.

Patrick Murray1, Gary W Chune, Vasudevan A Raghavan.   

Abstract

The United Kingdom Prospective Diabetes Study (UKPDS) and the Diabetes Chronic Complications Trial (DCCT) are two landmark trials that convincingly demonstrated that tight glycemic control has beneficial effects on microvascular end points. These studies also revealed a "legacy effect," which is a sustained benefit with respect to cardiovascular disease outcomes seen long after the conclusion of the trial. We discuss possible molecular mechanisms that could play a role in causing the legacy effect.

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Year:  2010        PMID： 20652839     DOI： 10.1007/s11883-010-0128-1

Source DB:  PubMed          Journal:  Curr Atheroscler Rep        ISSN： 1523-3804            Impact factor:   5.113


  52 in total

1.  Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats.

Authors:  Renu A Kowluru
Journal:  Diabetes       Date:  2003-03       Impact factor: 9.461

2.  Comorbidity affects the relationship between glycemic control and cardiovascular outcomes in diabetes: a cohort study.

Authors:  Sheldon Greenfield; John Billimek; Fabio Pellegrini; Monica Franciosi; Giorgia De Berardis; Antonio Nicolucci; Sherrie H Kaplan
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3.  Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory.

Authors:  S Roy; R Sala; E Cagliero; M Lorenzi
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

4.  Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus.

Authors:  David M Nathan; John Lachin; Patricia Cleary; Trevor Orchard; David J Brillon; Jye-Yu Backlund; Daniel H O'Leary; Saul Genuth
Journal:  N Engl J Med       Date:  2003-06-05       Impact factor: 91.245

5.  Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

Authors:  L Rossetti; G I Shulman; W Zawalich; R A DeFronzo
Journal:  J Clin Invest       Date:  1987-10       Impact factor: 14.808

6.  Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

Authors:  I Giardino; D Edelstein; M Brownlee
Journal:  J Clin Invest       Date:  1994-07       Impact factor: 14.808

7.  Hyperglycemia decreases glucose uptake in type I diabetes.

Authors:  H Yki-Järvinen; E Helve; V A Koivisto
Journal:  Diabetes       Date:  1987-08       Impact factor: 9.461

8.  Reactive oxygen species mediate a cellular 'memory' of high glucose stress signalling.

Authors:  M A Ihnat; J E Thorpe; C D Kamat; C Szabó; D E Green; L A Warnke; Z Lacza; A Cselenyák; K Ross; S Shakir; L Piconi; R C Kaltreider; A Ceriello
Journal:  Diabetologia       Date:  2007-05-17       Impact factor: 10.122

9.  Intensive glucose-lowering therapy reduces cardiovascular disease events in veterans affairs diabetes trial participants with lower calcified coronary atherosclerosis.

Authors:  Peter D Reaven; Thomas E Moritz; Dawn C Schwenke; Robert J Anderson; Michael Criqui; Robert Detrano; Nicholas Emanuele; Moti Kayshap; Jennifer Marks; Sunder Mudaliar; R Harsha Rao; Jayendra H Shah; Steven Goldman; Domenic J Reda; Madeline McCarren; Carlos Abraira; William Duckworth
Journal:  Diabetes       Date:  2009-08-03       Impact factor: 9.461

10.  Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy.

Authors:  Harn-Shen Chen; Tzu-En Wu; Tjin-Shing Jap; Li-Chuan Hsiao; Shen-Hung Lee; Hong-Da Lin
Journal:  Diabetes Care       Date:  2008-06-12       Impact factor: 17.152
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  24 in total

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Journal:  Curr Atheroscler Rep       Date:  2015-09       Impact factor: 5.113

2.  Can diabetes be surgically cured? Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus.

Authors:  Stacy A Brethauer; Ali Aminian; Héctor Romero-Talamás; Esam Batayyah; Jennifer Mackey; Laurence Kennedy; Sangeeta R Kashyap; John P Kirwan; Tomasz Rogula; Matthew Kroh; Bipan Chand; Philip R Schauer
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3.  Iberian Cured-Ham Consumption Improves Endothelial Function in Healthy Subjects.

Authors:  J Saban-Ruiz; M Fabregate-Fuente; R Fabregate-Fuente; A Andres-Castillo; A Palomino-Antolin; D Barrio-Carreras; L Martin-Fernandez; F Altamirano; C Fernandez-Fernandez; C Andres-Lacueva
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4.  Management of type-2 diabetes mellitus in adults: focus on individualizing non-insulin therapies.

Authors:  Luigi Brunetti; Julie Kalabalik
Journal:  P T       Date:  2012-12

5.  A multisite study of long-term remission and relapse of type 2 diabetes mellitus following gastric bypass.

Authors:  David E Arterburn; Andy Bogart; Nancy E Sherwood; Stephen Sidney; Karen J Coleman; Sebastien Haneuse; Patrick J O'Connor; Mary Kay Theis; Guilherme M Campos; David McCulloch; Joe Selby
Journal:  Obes Surg       Date:  2013-01       Impact factor: 4.129

6.  Association of Glycemic Status During Progression of Chronic Kidney Disease With Early Dialysis Mortality in Patients With Diabetes.

Authors:  Connie M Rhee; Csaba P Kovesdy; Vanessa A Ravel; Elani Streja; Steven M Brunelli; Melissa Soohoo; Keiichi Sumida; Miklos Z Molnar; Gregory A Brent; Danh V Nguyen; Kamyar Kalantar-Zadeh
Journal:  Diabetes Care       Date:  2017-06-07       Impact factor: 19.112

Review 7.  Role of metabolic surgery in less obese or non-obese subjects with type 2 diabetes: influence over cardiovascular events.

Authors:  Ricardo Cohen; Pedro Paulo Caravatto; Tarissa Petry; David Cummings
Journal:  Curr Atheroscler Rep       Date:  2013-10       Impact factor: 5.113

8.  Impacting obesity and glycemic control using a culturally-sensitive diabetes education program in Hispanic patients with type 2 diabetes.

Authors:  Ralph M Peterson; Larry Beeson; Eloy Shulz; Anthony Firek; Marino De Leon; Hector Balcazar; Serena Tonstad; Zaida R Cordero-Macintyre
Journal:  Int J Body Compos Res       Date:  2010

Review 9.  Management of Type 2 Diabetes - Methods for Addition of Prandial to Basal Insulin.

Authors:  W Rodbard Helena; Boris Karolicki
Journal:  Eur Endocrinol       Date:  2014-08-25

Review 10.  The Contribution of Diabetes Education in the Treatment of People with Type 2 Diabetes and Risk of Cardiovascular Disease.

Authors:  M G S Cavicchioli; C C L Guerbali; C Ochiai; R M Silva; G Camara; T B Z Petry
Journal:  Curr Atheroscler Rep       Date:  2016-07       Impact factor: 5.113
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