Literature DB >> 20652388

Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument.

Masafumi Harada1, Masako M Taki, Ayumi Nose, Hitoshi Kubo, Kenji Mori, Hiromu Nishitani, Tsuyoshi Matsuda.   

Abstract

Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu.

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Year:  2011        PMID： 20652388     DOI： 10.1007/s10803-010-1065-0

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  38 in total

1.  Measurement of variation in the human cerebral GABA level by in vivo MEGA-editing proton MR spectroscopy using a clinical 3 T instrument and its dependence on brain region and the female menstrual cycle.

Authors:  Masafumi Harada; Hitoshi Kubo; Ayumi Nose; Hiromu Nishitani; Tsuyoshi Matsuda
Journal:  Hum Brain Mapp       Date:  2011-05       Impact factor: 5.038

2.  In vivo detection of gray and white matter differences in GABA concentration in the human brain.

Authors:  In-Young Choi; Sang-Pil Lee; Hellmut Merkle; Jun Shen
Journal:  Neuroimage       Date:  2006-08-01       Impact factor: 6.556

3.  Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3.

Authors:  Rodney C Samaco; Amber Hogart; Janine M LaSalle
Journal:  Hum Mol Genet       Date:  2004-12-22       Impact factor: 6.150

4.  High-resolution proton magnetic resonance spectroscopy of rabbit brain: regional metabolite levels and postmortem changes.

Authors:  O A Petroff; T Ogino; J R Alger
Journal:  J Neurochem       Date:  1988-07       Impact factor: 5.372

5.  GABA changes with vigabatrin in the developing human brain.

Authors:  E J Novotny; F Hyder; M Shevell; D L Rothman
Journal:  Epilepsia       Date:  1999-04       Impact factor: 5.864

6.  Regional magnetic resonance spectroscopy of the brain in autistic individuals.

Authors:  S Hisaoka; M Harada; H Nishitani; K Mori
Journal:  Neuroradiology       Date:  2001-06       Impact factor: 2.804

7.  Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update.

Authors:  Charles J Coté; Stephen Wilson
Journal:  Pediatrics       Date:  2006-12       Impact factor: 7.124

8.  Histoanatomic observations of the brain in early infantile autism.

Authors:  M Bauman; T L Kemper
Journal:  Neurology       Date:  1985-06       Impact factor: 9.910

9.  Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra.

Authors:  Melissa Terpstra; Pierre-Gilles Henry; Rolf Gruetter
Journal:  Magn Reson Med       Date:  2003-07       Impact factor: 4.668

10.  In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism.

Authors:  Lisa A Page; Eileen Daly; Nicole Schmitz; Andrew Simmons; Fiona Toal; Quinton Deeley; Fiona Ambery; Grainne M McAlonan; Kieran C Murphy; Declan G M Murphy
Journal:  Am J Psychiatry       Date:  2006-12       Impact factor: 18.112
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  101 in total

Review 1.  GABA-based evaluation of neurologic conditions: MR spectroscopy.

Authors:  L M Levy; A J Degnan
Journal:  AJNR Am J Neuroradiol       Date:  2012-01-19       Impact factor: 3.825

2.  Does fever relieve autistic behavior by improving brain blood flow?

Authors:  Peter Good
Journal:  Neuropsychol Rev       Date:  2011-01-20       Impact factor: 7.444

3.  Reply to letter of Peter Good.

Authors:  Martha R Herbert
Journal:  Neuropsychol Rev       Date:  2011-01-19       Impact factor: 7.444

4.  c-Kit+ cells transplantation as a new treatment for autism, a novel hypothesis with important research and clinical implication.

Authors:  Ahmad Ghanizadeh
Journal:  J Autism Dev Disord       Date:  2011-11

Review 5.  1H-MRS in autism spectrum disorders: a systematic meta-analysis.

Authors:  Jonathan C Ipser; Supriya Syal; Judy Bentley; Colleen M Adnams; Bennie Steyn; Dan J Stein
Journal:  Metab Brain Dis       Date:  2012-03-18       Impact factor: 3.584

6.  Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder.

Authors:  Tamar Kolodny; Michael-Paul Schallmo; Jennifer Gerdts; Richard A E Edden; Raphael A Bernier; Scott O Murray
Journal:  Autism Res       Date:  2020-04-16       Impact factor: 5.216

7.  Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD.

Authors:  Russell G Port; William Gaetz; Luke Bloy; Dah-Jyuu Wang; Lisa Blaskey; Emily S Kuschner; Susan E Levy; Edward S Brodkin; Timothy P L Roberts
Journal:  Autism Res       Date:  2016-10-01       Impact factor: 5.216

8.  Relationship among Glutamine, γ-Aminobutyric Acid, and Social Cognition in Autism Spectrum Disorders.

Authors:  David M Cochran; Elif M Sikoglu; Steven M Hodge; Richard A E Edden; Ann Foley; David N Kennedy; Constance M Moore; Jean A Frazier
Journal:  J Child Adolesc Psychopharmacol       Date:  2015-04-28       Impact factor: 2.576

Review 9.  Exploring the multifactorial nature of autism through computational systems biology: calcium and the Rho GTPase RAC1 under the spotlight.

Authors:  Fares Zeidán-Chuliá; José Luiz Rybarczyk-Filho; Alla B Salmina; Ben-Hur Neves de Oliveira; Mami Noda; José Cláudio F Moreira
Journal:  Neuromolecular Med       Date:  2013-03-02       Impact factor: 3.843

10.  Targeting neurotensin as a potential novel approach for the treatment of autism.

Authors:  Ahmad Ghanizadeh
Journal:  J Neuroinflammation       Date:  2010-10-01       Impact factor: 8.322
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