Literature DB >> 20652371

Regulation of GSK3 isoforms by phosphatases PP1 and PP2A.

Félix Hernández1, Elena Langa, Raquel Cuadros, Jesús Avila, Nieves Villanueva.   

Abstract

Dephosphorylation of phospho GSK3 isoforms, from COS-7 cells, was determined in vitro and in cultured cells in the absence or the presence of okadaic acid and lithium. Our results indicate a preferential dephosphorylation of phospho GSK3α by PP2A phosphatase, whereas dephosphorylation of phospho GSK3β mainly takes place by PP1 phosphatase.

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Year:  2010        PMID: 20652371     DOI: 10.1007/s11010-010-0544-0

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN: 0300-8177            Impact factor:   3.396


  23 in total

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