| Literature DB >> 20652178 |
Paul Labeaume1, Ma Dong, Michail Sitkovsky, Elizabeth V Jones, Rhiannon Thomas, Sara Sadler, Amy E Kallmerten, Graham B Jones.
Abstract
A one-pot route to 8-substituted xanthines has been developed from 5,6-diaminouracils and carboxaldehydes. Yields are good and the process applicable to a range of substrates including a family of A(2A) adenosine receptor antagonists. A new route to the KW-6002 family of antagonists is presented including a pro-drug variant, and application to related image contrast agents developed.Entities:
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Year: 2010 PMID： 20652178 DOI： 10.1039/c003382k
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876