J M Kim1, K H Park, S H Kim, J H Kang, S W Cho. 1. Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
Abstract
OBJECTIVE: To evaluate the structural relationship between the cornea and the optic disc in normal subjects. METHODS: This hospital-based observational study included 205 eyes from 205 individuals who were diagnosed as normal at our glaucoma clinic. The subjects underwent an eye examination, optic disc imaging with optic disc photography, optical coherence tomography, IOL master, specular microscopy, and ultrasound corneal pachymetry. RESULTS: In univariate regression models (Pearson's correlation coefficient), the cup-to-disc (CD) ratio showed a negative correlation with corneal curvature (r=-0.315, P<0.001) and central corneal thickness (r=-0.206, P=0.005), and a positive correlation with white-to-white diameter (horizontal limbus to limbus distance, r=0.215, P=0.003). In multiple linear regression models with CD ratio as the dependant parameter, the CD ratio was still significantly associated with corneal curvature (β=-0.205, P=0.011) and white-to-white diameter (β=0.207, P=0.010). The central corneal thickness failed to show statistical significance, but did show a negative correlation with borderline significance (β=-0.133, P=0.075). CONCLUSIONS: Eyes with a large CD ratio have large and flat corneas; this may suggest that there is a structural relationship between the cornea and the optic disc. These results can be helpful in analysing the anatomical relationship between the cornea and the optic disc.
OBJECTIVE: To evaluate the structural relationship between the cornea and the optic disc in normal subjects. METHODS: This hospital-based observational study included 205 eyes from 205 individuals who were diagnosed as normal at our glaucoma clinic. The subjects underwent an eye examination, optic disc imaging with optic disc photography, optical coherence tomography, IOL master, specular microscopy, and ultrasound corneal pachymetry. RESULTS: In univariate regression models (Pearson's correlation coefficient), the cup-to-disc (CD) ratio showed a negative correlation with corneal curvature (r=-0.315, P<0.001) and central corneal thickness (r=-0.206, P=0.005), and a positive correlation with white-to-white diameter (horizontal limbus to limbus distance, r=0.215, P=0.003). In multiple linear regression models with CD ratio as the dependant parameter, the CD ratio was still significantly associated with corneal curvature (β=-0.205, P=0.011) and white-to-white diameter (β=0.207, P=0.010). The central corneal thickness failed to show statistical significance, but did show a negative correlation with borderline significance (β=-0.133, P=0.075). CONCLUSIONS: Eyes with a large CD ratio have large and flat corneas; this may suggest that there is a structural relationship between the cornea and the optic disc. These results can be helpful in analysing the anatomical relationship between the cornea and the optic disc.
Authors: Gauti Jóhannesson; Christina Lindén; Anders Eklund; Anders Behndig; Per Hallberg Journal: Graefes Arch Clin Exp Ophthalmol Date: 2014-07-17 Impact factor: 3.117
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