Literature DB >> 20651598

Adherence to immunosuppressants: how can it be improved in adolescent organ transplant recipients?

Emily M Fredericks1, Dawn Dore-Stites.   

Abstract

PURPOSE OF REVIEW: Nonadherence among pediatric transplant recipients is prevalent, with rates as high as 75% among adolescents. These rates are alarming given that adherence behavior has the potential to be modified. This review examines evidence from recent studies and position statements to determine the current issues related to improving medication adherence in adolescent transplant recipients. RECENT
FINDINGS: To date, there are no empirically validated treatments to promote adherence in pediatric transplant recipients. Yet, interventions in other chronic illness populations suggest that combined education and behavioral strategies are the most effective in improving medication adherence. The use of technology, such as the Internet and cellphones, provides a promising mechanism for delivering adherence-promoting interventions to adolescents. Preliminary studies in pediatric solid organ transplant suggest that interventions focused on targeted education and behavioral cues using cellphone text messages are promising strategies for promoting medication adherence.
SUMMARY: Strategies for promoting adherence in adolescent transplant recipients should include developmentally appropriate models and should incorporate health-related education, motivational strategies, and behavioral skills. Interventions should be tailored to meet individual needs, and should be a collaborative effort between the adolescent, family and healthcare providers.

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Year:  2010        PMID: 20651598      PMCID: PMC3092530          DOI: 10.1097/MOT.0b013e32833d3115

Source DB:  PubMed          Journal:  Curr Opin Organ Transplant        ISSN: 1087-2418            Impact factor:   2.640


  64 in total

Review 1.  Adherence to medication.

Authors:  Lars Osterberg; Terrence Blaschke
Journal:  N Engl J Med       Date:  2005-08-04       Impact factor: 91.245

Review 2.  Brief interventions and motivational interviewing with children, adolescents, and their parents in pediatric health care settings: a review.

Authors:  Sarah J Erickson; Melissa Gerstle; Sarah W Feldstein
Journal:  Arch Pediatr Adolesc Med       Date:  2005-12

3.  An information-motivation-behavioral skills model of adherence to antiretroviral therapy.

Authors:  Jeffrey D Fisher; William A Fisher; K Rivet Amico; Jennifer J Harman
Journal:  Health Psychol       Date:  2006-07       Impact factor: 4.267

Review 4.  Interventions to enhance medication adherence in chronic medical conditions: a systematic review.

Authors:  Sunil Kripalani; Xiaomei Yao; R Brian Haynes
Journal:  Arch Intern Med       Date:  2007-03-26

5.  A systematic review of internet-based self-management interventions for youth with health conditions.

Authors:  Jennifer Stinson; Rita Wilson; Navreet Gill; Janet Yamada; Jessica Holt
Journal:  J Pediatr Psychol       Date:  2008-11-23

6.  A novel approach to managing variation: outpatient therapeutic monitoring of calcineurin inhibitor blood levels in liver transplant recipients.

Authors:  John C Bucuvalas; Frederick C Ryckman; Gajra Arya; Brandy Andrew; Anne Lesko; Conrad R Cole; Brent James; Uma Kotagal
Journal:  J Pediatr       Date:  2005-06       Impact factor: 4.406

7.  A multicenter randomized controlled trial of motivational interviewing in teenagers with diabetes.

Authors:  Sue J Channon; Michelle V Huws-Thomas; Stephen Rollnick; Kerenza Hood; Rebecca L Cannings-John; Carol Rogers; John W Gregory
Journal:  Diabetes Care       Date:  2007-03-10       Impact factor: 19.112

8.  Evaluation of an internet diabetes self-management training program for adolescents and young adults.

Authors:  Ben S Gerber; Marla C Solomon; Tracie L Shaffer; Michael T Quinn; Rebecca B Lipton
Journal:  Diabetes Technol Ther       Date:  2007-02       Impact factor: 6.118

Review 9.  Interventions to enhance medication adherence.

Authors:  R B Haynes; X Yao; A Degani; S Kripalani; A Garg; H P McDonald
Journal:  Cochrane Database Syst Rev       Date:  2005-10-19

10.  The challenges of using medication event monitoring technology with pediatric transplant patients.

Authors:  Diana A Shellmer; Nataliya Zelikovsky
Journal:  Pediatr Transplant       Date:  2007-06
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  12 in total

Review 1.  Nonadherence to immunosuppressive therapy in kidney transplant recipients: can technology help?

Authors:  Erika Nerini; Fulvio Bruno; Franco Citterio; Francesco P Schena
Journal:  J Nephrol       Date:  2016-02-17       Impact factor: 3.902

Review 2.  Tolerance--is it worth it?

Authors:  Erik B Finger; Terry B Strom; Arthur J Matas
Journal:  Cold Spring Harb Perspect Med       Date:  2014-02-01       Impact factor: 6.915

Review 3.  The Evolution of Lung Transplant Immunosuppression.

Authors:  Steven Ivulich; Glen Westall; Michael Dooley; Gregory Snell
Journal:  Drugs       Date:  2018-07       Impact factor: 9.546

4.  Inferior allograft outcomes in adolescent recipients of renal transplants from ideal deceased donors.

Authors:  Matthew H Levine; Peter P Reese; Alexander Wood; Jorge H Baluarte; Ari Huverserian; Ali Naji; Peter L Abt
Journal:  Ann Surg       Date:  2012-03       Impact factor: 12.969

Review 5.  Research Needs for Effective Transition in Lifelong Care of Congenital Genitourinary Conditions: A Workshop Sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases.

Authors:  Michael H Hsieh; Hadley M Wood; Brad E Dicianno; Nienke P Dosa; Veronica Gomez-Lobo; Tej K Mattoo; Rosalia Misseri; Jenna M Norton; Kathleen J Sawin; Peter Scal; James E Wright; Robert A Star; Tamara Bavendam
Journal:  Urology       Date:  2017-02-02       Impact factor: 2.649

6.  Randomized pilot trial of praise text messages to improve medication adherence among adolescents and young adults with liver transplants.

Authors:  Caitlin Sayegh; Deborah Im; Ilana K Moss; Ruby Urquiza; Shreena Patel; Dan W Thomas
Journal:  Pediatr Transplant       Date:  2022-07-19

7.  Managing bronchiolitis obliterans syndrome (BOS) and chronic lung allograft dysfunction (CLAD) in children: what does the future hold?

Authors:  Gregory I Snell; Miranda Paraskeva; Glen P Westall
Journal:  Paediatr Drugs       Date:  2013-08       Impact factor: 3.022

Review 8.  Post-transplant adjustment--the later years.

Authors:  Emily M Fredericks; Nataliya Zelikovsky; Isabelle Aujoulat; Anna Hames; Jo Wray
Journal:  Pediatr Transplant       Date:  2014-09-13

Review 9.  Hypertension and obesity after pediatric kidney transplantation: management based on pathophysiology: a mini review.

Authors:  Eunice G John; Liezl T Domingo
Journal:  Int J Prev Med       Date:  2014-03

Review 10.  A systematic review of self-management interventions for children and youth with physical disabilities.

Authors:  Sally Lindsay; Shauna Kingsnorth; Carolyn Mcdougall; Heather Keating
Journal:  Disabil Rehabil       Date:  2013-04-24       Impact factor: 3.033

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