BACKGROUND: Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity. MATERIALS AND METHODS: The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach. RESULTS: The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1. CONCLUSION: The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway.
BACKGROUND:Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity. MATERIALS AND METHODS: The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach. RESULTS: The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1. CONCLUSION: The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway.
Authors: Baljinder Kaur; Rajan Rolta; Deeksha Salaria; Balvir Kumar; Olatomide A Fadare; Renato Araujo da Costa; Ajaz Ahmad; Mahmood Basil A Al-Rawi; Mohammad Raish; Irfan A Rather Journal: Molecules Date: 2022-06-24 Impact factor: 4.927
Authors: C C Estanislao Gómez; A Aquino Carreño; D G Pérez Ishiwara; E San Martín Martínez; J Morales López; N Pérez Hernández; M C Gómez García Journal: BMC Complement Altern Med Date: 2016-08-05 Impact factor: 3.659