OBJECTIVE: Optical and radiologic imaging are commonly used in preclinical research, and research into combined instruments for human applications is showing promise. The purpose of this article is to outline the fundamental limitations and advantages and to review the available systems. The emerging developments and future potential will be summarized. CONCLUSION: Integration of hybrid systems is now routine at the preclinical level and appears in the form of specialized packages in which performance varies considerably. The synergy is commonly focused on using spatial localization from radiographs to provide structural data for spectroscopy; however, applications also exist in which the spectroscopy informs the use of radiologic imaging. Examples of clinical systems under research and development are shown.
OBJECTIVE: Optical and radiologic imaging are commonly used in preclinical research, and research into combined instruments for human applications is showing promise. The purpose of this article is to outline the fundamental limitations and advantages and to review the available systems. The emerging developments and future potential will be summarized. CONCLUSION: Integration of hybrid systems is now routine at the preclinical level and appears in the form of specialized packages in which performance varies considerably. The synergy is commonly focused on using spatial localization from radiographs to provide structural data for spectroscopy; however, applications also exist in which the spectroscopy informs the use of radiologic imaging. Examples of clinical systems under research and development are shown.
Authors: David R Busch; Wensheng Guo; Regine Choe; Turgut Durduran; Michael D Feldman; Carolyn Mies; Mark A Rosen; Mitchell D Schnall; Brian J Czerniecki; Julia Tchou; Angela DeMichele; Mary E Putt; Arjun G Yodh Journal: Med Phys Date: 2010-04 Impact factor: 4.071
Authors: Daniel Floery; Thomas H Helbich; Christopher C Riedl; Silvia Jaromi; Michael Weber; Sepp Leodolter; Michael H Fuchsjaeger Journal: Invest Radiol Date: 2005-06 Impact factor: 6.016
Authors: Xuefeng Cheng; Jian-min Mao; Robin Bush; Daniel B Kopans; Richard H Moore; Maryann Chorlton Journal: Appl Opt Date: 2003-11-01 Impact factor: 1.980
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Authors: Hoon Hyun; Min Ho Park; Eric A Owens; Hideyuki Wada; Maged Henary; Henricus J M Handgraaf; Alexander L Vahrmeijer; John V Frangioni; Hak Soo Choi Journal: Nat Med Date: 2015-01-05 Impact factor: 53.440