Literature DB >> 20651165

Resolved: EMT produces fibroblasts in the kidney.

Michael Zeisberg1, Jeremy S Duffield.   

Abstract

Epithelial-mesenchymal transition (EMT) is a mechanism for generating primitive mesenchymal cells during gastrulation or mobile tumor cells during cancer metastasis. For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate.

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Year:  2010        PMID： 20651165     DOI： 10.1681/ASN.2010060616

Source DB:  PubMed          Journal:  J Am Soc Nephrol        ISSN： 1046-6673            Impact factor:   10.121


  105 in total

Review 1.  Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases.

Authors:  Paola Nisticò; Mina J Bissell; Derek C Radisky
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-02-01       Impact factor: 10.005

Review 2.  Recent developments in myofibroblast biology: paradigms for connective tissue remodeling.

Authors:  Boris Hinz; Sem H Phan; Victor J Thannickal; Marco Prunotto; Alexis Desmoulière; John Varga; Olivier De Wever; Marc Mareel; Giulio Gabbiani
Journal:  Am J Pathol       Date:  2012-03-02       Impact factor: 4.307

Review 3.  Cellular and molecular mechanisms of renal fibrosis.

Authors:  Youhua Liu
Journal:  Nat Rev Nephrol       Date:  2011-10-18       Impact factor: 28.314

4.  Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE.

Authors:  Matthew Rozycki; Janne Folke Bialik; Pam Speight; Qinghong Dan; Teresa E T Knudsen; Stephen G Szeto; Darren A Yuen; Katalin Szászi; Stine F Pedersen; András Kapus
Journal:  J Biol Chem       Date:  2015-11-10       Impact factor: 5.157

Review 5.  MicroRNAs as mediators and therapeutic targets in chronic kidney disease.

Authors:  Johan M Lorenzen; Hermann Haller; Thomas Thum
Journal:  Nat Rev Nephrol       Date:  2011-03-22       Impact factor: 28.314

6.  Chronic kidney disease: Fibrosis and anaemia in CKD--two beasts, one ancestor.

Authors:  Liangxiang Xiao; Youhua Liu
Journal:  Nat Rev Nephrol       Date:  2013-09-03       Impact factor: 28.314

Review 7.  Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis.

Authors:  Gabriela Campanholle; Giovanni Ligresti; Sina A Gharib; Jeremy S Duffield
Journal:  Am J Physiol Cell Physiol       Date:  2013-01-16       Impact factor: 4.249

Review 8.  Host responses in tissue repair and fibrosis.

Authors:  Jeremy S Duffield; Mark Lupher; Victor J Thannickal; Thomas A Wynn
Journal:  Annu Rev Pathol       Date:  2012-10-22       Impact factor: 23.472

9.  The differential expression of TGF-β1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study.

Authors:  Min-Kyung Kim; Young-In Maeng; Woo Jung Sung; Hoon-Kyu Oh; Jae-Bok Park; Ghil Suk Yoon; Chang-Ho Cho; Kwan-Kyu Park
Journal:  Int J Clin Exp Pathol       Date:  2013-08-15

Review 10.  TGF-β1 Signaling and Tissue Fibrosis.

Authors:  Kevin K Kim; Dean Sheppard; Harold A Chapman
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-04-02       Impact factor: 10.005
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