RATIONALE AND OBJECTIVES: Gadofosveset trisodium is a blood-pool contrast agent (BPA) that shows a less pronounced r1 relaxivity advantage over gadobenate dimeglumine at 3T than at 1.5T. However, there are few data on image quality during first-pass imaging of the thoracic vasculature with gadofosveset trisodium at 3 T. Therefore, it was the aim of this study to compare first-pass imaging characteristics of gadofosveset trisodium to gadobenate dimeglumine during time-resolved contrast-enhanced three-dimensional magnetic resonance angiography (CE MRA) at 3 T. MATERIALS AND METHODS: Twenty volunteers underwent time-resolved CE MRA on a 3 T magnetic resonance (MR) system with a standard eight-channel phased-array surface coil, receiving either gadofosveset trisodium (blood pool agent [BPA], n = 10) or gadobenate dimeglumine (standard contrast agent, [SCA], n = 10). Image quality was assessed by two independent readers using a Likert scale ranging from 0 = poor quality to 3 = excellent quality, and relative signal-to-noise and contrast-to-noise ratios were calculated. RESULTS: Equally good to excellent first-pass image quality was confirmed for time-resolved CE MRA using BPA and SCA (arteries, 2.8 ± 0.2 and 2.6 ± 0.4; veins, 2.5 ± 0.3 and 2.2 ± 0.4; artifacts, 2.4 ± 0.2 and 2.3 ± 0.1). Signal-to-noise and contrast-to-noise ratios showed nonsignificant differences, except for left subclavian artery values. There was an overall nonsignificant superiority in signal-to-noise and contrast-to-noise ratios for standard contrast agent in arterial values and BPA regarding venous values. CONCLUSIONS: Despite a markedly decreased r1/r2 relaxivity ratio, first-pass imaging characteristics of gadofosveset trisodium and gadobenate dimeglumine are equally well suited for first pass time-resolved CE MRA at 3 T.
RATIONALE AND OBJECTIVES:Gadofosveset trisodium is a blood-pool contrast agent (BPA) that shows a less pronounced r1 relaxivity advantage over gadobenate dimeglumine at 3T than at 1.5T. However, there are few data on image quality during first-pass imaging of the thoracic vasculature with gadofosveset trisodium at 3 T. Therefore, it was the aim of this study to compare first-pass imaging characteristics of gadofosveset trisodium to gadobenate dimeglumine during time-resolved contrast-enhanced three-dimensional magnetic resonance angiography (CE MRA) at 3 T. MATERIALS AND METHODS: Twenty volunteers underwent time-resolved CE MRA on a 3 T magnetic resonance (MR) system with a standard eight-channel phased-array surface coil, receiving either gadofosveset trisodium (blood pool agent [BPA], n = 10) or gadobenate dimeglumine (standard contrast agent, [SCA], n = 10). Image quality was assessed by two independent readers using a Likert scale ranging from 0 = poor quality to 3 = excellent quality, and relative signal-to-noise and contrast-to-noise ratios were calculated. RESULTS: Equally good to excellent first-pass image quality was confirmed for time-resolved CE MRA using BPA and SCA (arteries, 2.8 ± 0.2 and 2.6 ± 0.4; veins, 2.5 ± 0.3 and 2.2 ± 0.4; artifacts, 2.4 ± 0.2 and 2.3 ± 0.1). Signal-to-noise and contrast-to-noise ratios showed nonsignificant differences, except for left subclavian artery values. There was an overall nonsignificant superiority in signal-to-noise and contrast-to-noise ratios for standard contrast agent in arterial values and BPA regarding venous values. CONCLUSIONS: Despite a markedly decreased r1/r2 relaxivity ratio, first-pass imaging characteristics of gadofosveset trisodium and gadobenate dimeglumine are equally well suited for first pass time-resolved CE MRA at 3 T.
Authors: Barbara E U Burkhardt; Nicholas K Brown; Jaclyn E Carberry; Marí Nieves Velasco Forte; Nicholas Byrne; Gerald Greil; Tarique Hussain; Animesh Tandon Journal: Int J Cardiovasc Imaging Date: 2019-06-15 Impact factor: 2.357
Authors: Susanne Schnell; Danielle A Smith; Alex J Barker; Pegah Entezari; Amir R Honarmand; Maria L Carr; S Chris Malaisrie; Patrick M McCarthy; Jeremy Collins; James C Carr; Michael Markl Journal: Eur Heart J Cardiovasc Imaging Date: 2016-07-26 Impact factor: 6.875
Authors: Fabio S Raman; Marcelo S Nacif; George Cater; Neville Gai; Jacquin Jones; Debiao Li; Christopher T Sibley; Songtao Liu; David A Bluemke Journal: Int J Cardiovasc Imaging Date: 2013-03-21 Impact factor: 2.357
Authors: G Paul Camren; Gregory J Wilson; Vikram R Bamra; Khahn Q Nguyen; Daniel S Hippe; Jeffrey H Maki Journal: Biomed Res Int Date: 2014-06-29 Impact factor: 3.411
Authors: Mark A Ahlman; Fabio S Raman; Jianing Pang; Filip Zemrak; Veit Sandfort; Scott R Penzak; Zhaoyang Fan; Songtao Liu; Debiao Li; David A Bluemke Journal: BMC Cardiovasc Disord Date: 2016-03-22 Impact factor: 2.298