Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Interleukin-12 as an adjuvant for induction of protective antibody responses.

Literature DB >> 20650650

Interleukin-12 as an adjuvant for induction of protective antibody responses.

Abstract

Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20650650 PMCID： PMC2935143 DOI： 10.1016/j.cyto.2010.06.011

Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861

50 in total

1. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.

Authors: M Marinaro; H F Staats; T Hiroi; R J Jackson; M Coste; P N Boyaka; N Okahashi; M Yamamoto; H Kiyono; H Bluethmann; K Fujihashi; J R McGhee
Journal: J Immunol Date: 1995-11-15 Impact factor: 5.422

Review 2. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses.

Authors: M K Gately; L M Renzetti; J Magram; A S Stern; L Adorini; U Gubler; D H Presky
Journal: Annu Rev Immunol Date: 1998 Impact factor: 28.527

3. Direct binding of IL-12 to human and murine B lymphocytes.

Authors: L A Vogel; L C Showe; T L Lester; R M McNutt; V H Van Cleave; D W Metzger
Journal: Int Immunol Date: 1996-12 Impact factor: 4.823

4. Enhancement of humoral immunity by interleukin-12.

Authors: D W Metzger; J M Buchanan; J T Collins; T L Lester; K S Murray; V H Van Cleave; L A Vogel; W A Dunnick
Journal: Ann N Y Acad Sci Date: 1996-10-31 Impact factor: 5.691

5. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells.

Authors: T Yoshimoto; H Okamura; Y I Tagawa; Y Iwakura; K Nakanishi
Journal: Proc Natl Acad Sci U S A Date: 1997-04-15 Impact factor: 11.205

6. Interleukin-12 acts as an adjuvant for humoral immunity through interferon-gamma-dependent and -independent mechanisms.

Authors: D W Metzger; R M McNutt; J T Collins; J M Buchanan; V H Van Cleave; W A Dunnick
Journal: Eur J Immunol Date: 1997-08 Impact factor: 5.532

7. IL-12 deaths: explanation and a puzzle.

Authors: J Cohen
Journal: Science Date: 1995-11-10 Impact factor: 47.728

8. IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response.

Authors: J Bliss; V Van Cleave; K Murray; A Wiencis; M Ketchum; R Maylor; T Haire; C Resmini; A K Abbas; S F Wolf
Journal: J Immunol Date: 1996-02-01 Impact factor: 5.422

9. Differential regulation of the interleukin-12 receptor during the innate immune response to Leishmania major.

Authors: D Jones; M M Elloso; L Showe; D Williams; G Trinchieri; P Scott
Journal: Infect Immun Date: 1998-08 Impact factor: 3.441

10. Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge.

Authors: Y Chvatchko; M H Kosco-Vilbois; S Herren; J Lefort; J Y Bonnefoy
Journal: J Exp Med Date: 1996-12-01 Impact factor: 14.307

15 in total

1. Pulmonary macrophage subpopulations in the induction and resolution of acute lung injury.

Authors: Laura K Johnston; Cliff R Rims; Sean E Gill; John K McGuire; Anne M Manicone
Journal: Am J Respir Cell Mol Biol Date: 2012-06-21 Impact factor: 6.914

2. Feline immunodeficiency virus (FIV) vaccine efficacy and FIV neutralizing antibodies.

Authors: James K Coleman; Ruiyu Pu; Marcus M Martin; Ezra N Noon-Song; Raphael Zwijnenberg; Janet K Yamamoto
Journal: Vaccine Date: 2013-06-22 Impact factor: 3.641

3. Intranasal administration of an inactivated Yersinia pestis vaccine with interleukin-12 generates protective immunity against pneumonic plague.

Authors: Devender Kumar; Girish Kirimanjeswara; Dennis W Metzger
Journal: Clin Vaccine Immunol Date: 2011-08-31

Review 4. IL12Rβ1: the cytokine receptor that we used to know.

Authors: Richard T Robinson
Journal: Cytokine Date: 2014-12-13 Impact factor: 3.861

5. Enhancement of adaptive immunity to Neisseria gonorrhoeae by local intravaginal administration of microencapsulated interleukin 12.

Authors: Yingru Liu; Nejat K Egilmez; Michael W Russell
Journal: J Infect Dis Date: 2013-09-18 Impact factor: 5.226

6. Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists.

Authors: Michael A Collier; Robert D Junkins; Matthew D Gallovic; Brandon M Johnson; Monica M Johnson; Andrew N Macintyre; Gregory D Sempowski; Eric M Bachelder; Jenny P-Y Ting; Kristy M Ainslie
Journal: Mol Pharm Date: 2018-10-15 Impact factor: 4.939

7. Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.

Authors: Kristi Baker; Timo Rath; Magdalena B Flak; Janelle C Arthur; Zhangguo Chen; Jonathan N Glickman; Inti Zlobec; Eva Karamitopoulou; Matthew D Stachler; Robert D Odze; Wayne I Lencer; Christian Jobin; Richard S Blumberg
Journal: Immunity Date: 2013-11-27 Impact factor: 31.745