Literature DB >> 2064976

Rapid changes in concentrations of essential elements in organs of rats exposed to methylmercury chloride and mercuric chloride as shown by simultaneous multielemental analysis.

H Muto1, M Shinada, K Tokuta, Y Takizawa.   

Abstract

An in vivo study of rats given a dominant lethal dose of methylmercury chloride (MMC) or mercuric chloride (HgCl2) was conducted to elucidate the rapid biotransformation of essential elements. The elements were measured by inductively coupled plasma atomic emission spectrometry. For the rat brain Zn concentrations were higher in the MMC group than in the HgCl2 and control groups. The highest Cu concentration was found in HgCl2 dosed rat liver. For the rat kidney the highest Zn concentration was seen in the MMC group. From principal component analysis on the time dependent behaviour of each element in rat organs, characteristics specific to Cu in the liver and kidney and Mn in the brain were found after exposure to HgCl2 and Ca and Zn in the brain after exposure to MMC.

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Year:  1991        PMID： 2064976      PMCID： PMC1035382          DOI： 10.1136/oem.48.6.382

Source DB:  PubMed          Journal:  Br J Ind Med        ISSN： 0007-1072


  16 in total

1.  Characterization by Hg2+ of two different pathways for mitochondrial Ca2+ release.

Authors:  E Chávez; C Zazueta; E Díaz; J A Holquín
Journal:  Biochim Biophys Acta       Date:  1989-11-17

2.  Uptake of mercury by the brain.

Authors:  L Magos
Journal:  Br J Ind Med       Date:  1968-10

Review 3.  Functions of metallothionein.

Authors:  M Webb; K Cain
Journal:  Biochem Pharmacol       Date:  1982-01-15       Impact factor: 5.858

4.  Metabolism of zinc and copper in the neonate. (Zinc, copper)-thionein in the developing rat kidney and testis.

Authors:  F O Brady; M Webb
Journal:  J Biol Chem       Date:  1981-04-25       Impact factor: 5.157

5.  Fusion of phospholipid vesicles induced by Zn2+, Cd2+, and Hg2+.

Authors:  K D Barfield; D R Bevan
Journal:  Biochem Biophys Res Commun       Date:  1985-04-16       Impact factor: 3.575

6.  Urinary metallothionein and tissue metal levels of rats injected with cadmium, mercury, lead, copper or zinc.

Authors:  Y H Lee; Z A Shaikh; C Tohyama
Journal:  Toxicology       Date:  1983 Jul-Aug       Impact factor: 4.221

7.  Effect of Ca2+, peroxides, SH reagents, phosphate and aging on the permeability of mitochondrial membranes.

Authors:  R Rizzuto; G Pitton; G F Azzone
Journal:  Eur J Biochem       Date:  1987-01-15

8.  Hemoglobin-catalyzed lipid peroxidation in the presence of mercuric chloride.

Authors:  S R Ribarov; L C Benov; V I Marcova; I C Benchev
Journal:  Chem Biol Interact       Date:  1983-07-01       Impact factor: 5.192

9.  The interaction of cadium-induced rat renal metallothionein with bivalent mercury in vitro.

Authors:  D Holt; L Magos; M Webb
Journal:  Chem Biol Interact       Date:  1980-10       Impact factor: 5.192

10.  Effects of dietary mercury level and cadmium on rat tissue metallothionein: mercury binding and influences on zinc.

Authors:  P D Whanger; J T Deagen
Journal:  Environ Res       Date:  1983-04       Impact factor: 6.498
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  2 in total

1.  The effects of prenatal methylmercury exposure on trace element and antioxidant levels in rats following 6-hydroxydopamine-induced neuronal insult.

Authors:  Zulfiah Mohamed Moosa; Willie M U Daniels; Musa V Mabandla
Journal:  Metab Brain Dis       Date:  2013-12-17       Impact factor: 3.584

2.  Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.

Authors:  M Blanusa; L Prester; S Radić; B Kargacin
Journal:  Environ Health Perspect       Date:  1994-09       Impact factor: 9.031
  2 in total

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