BACKGROUND: Acute decompensated heart failure (HF) is a serious complication associated with significant morbidity and mortality. The CA-125 and NT-proBNP levels have been shown in some studies to predict the outcome, however, the prognostic value of other simple clinical parameters such as pleural effusion has not been established yet. AIM: To assess the prognostic value of pleural effusion regarding in-hospital and 6-month follow-up outcome in patients with acute decompensated HF and the relationship between pleural effusion and CA-125 and NT-proBNP levels. METHODS AND RESULTS: The CA-125 and NT-proBNP levels were measured at baseline and the presence of pleural effusion was examined on chest radiograms. One hundred patients were prospectively followed until the occurrence of cardiac death, defined as death from worsening HF or sudden cardiac death, or completion of follow-up period. There were 27 deaths over the course of 6 months of follow-up. An insignificant trend towards higher values of CA-125 was found in patients with pleural effusion. Univariate Cox regression analysis showed that there was no relationship between pleural effusion and in-hospital outcome as well as mortality during 6-month follow-up. The CA-125 and NT-proBNP levels predicted mortality. Multivariate Cox regression analysis showed that only CA-125 was an independent predictor of the 6-month outcome (RR: 1.2; 1.04-1.4; p = 0.001). CONCLUSIONS: In patients with acute decompensated HF, accompanying pleural effusion did not predict mortality or rehospitalisation during the 6-month follow-up. The increased CA-125 level was found to be an independent predictor of poor outcome, irrespective of pleural effusion.
BACKGROUND: Acute decompensated heart failure (HF) is a serious complication associated with significant morbidity and mortality. The CA-125 and NT-proBNP levels have been shown in some studies to predict the outcome, however, the prognostic value of other simple clinical parameters such as pleural effusion has not been established yet. AIM: To assess the prognostic value of pleural effusion regarding in-hospital and 6-month follow-up outcome in patients with acute decompensated HF and the relationship between pleural effusion and CA-125 and NT-proBNP levels. METHODS AND RESULTS: The CA-125 and NT-proBNP levels were measured at baseline and the presence of pleural effusion was examined on chest radiograms. One hundred patients were prospectively followed until the occurrence of cardiac death, defined as death from worsening HF or sudden cardiac death, or completion of follow-up period. There were 27 deaths over the course of 6 months of follow-up. An insignificant trend towards higher values of CA-125 was found in patients with pleural effusion. Univariate Cox regression analysis showed that there was no relationship between pleural effusion and in-hospital outcome as well as mortality during 6-month follow-up. The CA-125 and NT-proBNP levels predicted mortality. Multivariate Cox regression analysis showed that only CA-125 was an independent predictor of the 6-month outcome (RR: 1.2; 1.04-1.4; p = 0.001). CONCLUSIONS: In patients with acute decompensated HF, accompanying pleural effusion did not predict mortality or rehospitalisation during the 6-month follow-up. The increased CA-125 level was found to be an independent predictor of poor outcome, irrespective of pleural effusion.
Authors: Erin M DeBiasi; Margaret A Pisani; Terrence E Murphy; Katy Araujo; Anna Kookoolis; A Christine Argento; Jonathan Puchalski Journal: Eur Respir J Date: 2015-04-02 Impact factor: 16.671
Authors: Pasqualina L Santaguida; Andrew C Don-Wauchope; Mark Oremus; Robert McKelvie; Usman Ali; Stephen A Hill; Cynthia Balion; Ronald A Booth; Judy A Brown; Amy Bustamam; Nazmul Sohel; Parminder Raina Journal: Heart Fail Rev Date: 2014-08 Impact factor: 4.214
Authors: Muhammed Oylumlu; Vedat Davutoglu; Murat Sucu; Suleyman Ercan; Orhan Ozer; Murat Yuce Journal: Int J Cardiovasc Imaging Date: 2014-04-08 Impact factor: 2.357
Authors: Ka Hou Christien Li; Mengqi Gong; Guangping Li; Adrian Baranchuk; Tong Liu; Martin C S Wong; Aaron Jesuthasan; Rachel W C Lai; Jenny Chi Ling Lai; Alex Pui Wai Lee; Antoni Bayés-Genis; Rafael de la Espriella; Juan Sanchis; William K K Wu; Gary Tse; Julio Nuñez Journal: Heart Asia Date: 2018-10-26
Authors: Musa Çakıcı; Adnan Doğan; Mustafa Çetin; Arif Süner; Mustafa Polat; Muhammed Oylumlu; Erdal Aktürk; Sabri Abus; Fatih Üçkardeş Journal: Anatol J Cardiol Date: 2014-06-23 Impact factor: 1.596
Authors: Eleftherios Markatis; Garifallia Perlepe; Andreas Afthinos; Konstantinos Pagkratis; Charalampos Varsamas; Eleftheria Chaini; Ilias C Papanikolaou; Konstantinos I Gourgoulianis Journal: Front Med (Lausanne) Date: 2022-02-24
Authors: Moritz Lindner; Richard Thomas; Brian Claggett; Eldrin F Lewis; John Groarke; Allison A Merz; Montane B Silverman; Varsha Swamy; Jose Rivero; Christian Hohenstein; Scott D Solomon; John Jv McMurray; Michael L Steigner; Elke Platz Journal: Eur Heart J Acute Cardiovasc Care Date: 2020-01-24