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Literature DB >> 20643898

ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation.

Emmanuel González-Ortega¹, Maria-Pau Mena, Marc Permanyer, Ester Ballana, Bonaventura Clotet, José A Esté.

Abstract

We had shown that virus resistance to ADS-J1 was associated with amino acid changes in the envelope glycoprotein, mostly located in the gp120 coding region. Time-of-addition and endocytic virus transfer assays clearly demonstrated that ADS-J1 behaved as a gp120 inhibitor. ADS-J1-resistant virus was cross-resistant to the polyanion dextran sulfate, and recombination of gp120 recovered only the ADS-J1-resistant phenotype. In summary, ADS-J1 blocks an early step of virus entry that appears to be driven by gp120 alone.

Entities: Chemical Gene Species

Mesh：

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Year: 2010 PMID： 20643898 PMCID： PMC2944580 DOI： 10.1128/AAC.00359-10

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

44 in total

1. A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity.

Authors: Fabrizio Manetti; Cristina Tintori; Mercedes Armand-Ugón; Imma Clotet-Codina; Silvio Massa; Rino Ragno; José A Esté; Maurizio Botta
Journal: J Chem Inf Model Date: 2006 May-Jun Impact factor: 4.956

2. HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro.

Authors: Gemma Moncunill; Mercedes Armand-Ugón; Eduardo Pauls; Bonaventura Clotet; José A Esté
Journal: AIDS Date: 2008-01-02 Impact factor: 4.177

Review 3. HIV entry inhibitors.

Authors: José A Esté; Amalio Telenti
Journal: Lancet Date: 2007-07-07 Impact factor: 79.321

4. Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope.

Authors: Kathryn M Kitrinos; Heather Amrine-Madsen; David M Irlbeck; J Michael Word; James F Demarest
Journal: Antimicrob Agents Chemother Date: 2008-12-15 Impact factor: 5.191

5. A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.

Authors: Berta Bosch; Boyan Grigorov; Jordi Senserrich; Bonaventura Clotet; Jean-Luc Darlix; Delphine Muriaux; José A Este
Journal: Antiviral Res Date: 2008-07-03 Impact factor: 5.970

6. Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein.

Authors: Berta Bosch; Julià Blanco; Eduardo Pauls; Imma Clotet-Codina; Mercedes Armand-Ugón; Boyan Grigorov; Delphine Muriaux; Bonaventura Clotet; Jean-Luc Darlix; José A Esté
Journal: Antimicrob Agents Chemother Date: 2005-10 Impact factor: 5.191

7. Multiparametric assay to screen and dissect the mode of action of anti-human immunodeficiency virus envelope drugs.

Authors: Julià Blanco; Imma Clotet-Codina; Berta Bosch; Mercedes Armand-Ugón; Bonaventura Clotet; José A Esté
Journal: Antimicrob Agents Chemother Date: 2005-09 Impact factor: 5.191

8. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses.

Authors: Wolfgang Hübner; Gregory P McNerney; Ping Chen; Benjamin M Dale; Ronald E Gordon; Frank Y S Chuang; Xiao-Dong Li; David M Asmuth; Thomas Huser; Benjamin K Chen
Journal: Science Date: 2009-03-27 Impact factor: 47.728

9. Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages.

Authors: Ester Ballana; Eduardo Pauls; Jordi Senserrich; Bonaventura Clotet; Françoise Perron-Sierra; Gordon C Tucker; José A Esté
Journal: Blood Date: 2008-10-07 Impact factor: 22.113

10. Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.

Authors: Gemma Moncunill; Mercedes Armand-Ugón; Imma Clotet-Codina; Eduardo Pauls; Ester Ballana; Anuska Llano; Barbara Romagnoli; Jan W Vrijbloed; Frank O Gombert; Bonaventura Clotet; Steve De Marco; José A Esté
Journal: Mol Pharmacol Date: 2008-01-08 Impact factor: 4.436

8 in total

1. ADS-J1 inhibits semen-derived amyloid fibril formation and blocks fibril-mediated enhancement of HIV-1 infection.

Authors: Tianrong Xun; Wenjuan Li; Jinquan Chen; Fei Yu; Wei Xu; Qian Wang; Ruizhe Yu; Xiaojuan Li; Xuefeng Zhou; Lu Lu; Shibo Jiang; Lin Li; Suiyi Tan; Shuwen Liu
Journal: Antimicrob Agents Chemother Date: 2015-06-08 Impact factor: 5.191

2. [ADS-J1 antagonizes semen-derived enhancer of virus infection-mediated enhancement of transmitted founder HIV-1 and its matched chronic control strain infection].

Authors: Hong-Miao Liu; Ning-Ning Ma; Chun Luo; Shu-Ying Yuan; Fu-Li Liu; Xin-Gang Yao; Chun-Qiong Zhou; Min Zou
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2018-02-20

ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation.

1. A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity.

2. HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro.

Review 3. HIV entry inhibitors.

4. Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope.

5. A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.

6. Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein.

7. Multiparametric assay to screen and dissect the mode of action of anti-human immunodeficiency virus envelope drugs.

8. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses.

9. Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages.

10. Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.

1. ADS-J1 inhibits semen-derived amyloid fibril formation and blocks fibril-mediated enhancement of HIV-1 infection.

2. [ADS-J1 antagonizes semen-derived enhancer of virus infection-mediated enhancement of transmitted founder HIV-1 and its matched chronic control strain infection].

3. Antiretroviral agents effectively block HIV replication after cell-to-cell transfer.

Review 4. Small-Molecule HIV Entry Inhibitors Targeting gp120 and gp41.

Review 5. Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41.

Review 6. Small-Molecule Inhibition of Viral Fusion Glycoproteins.

Review 7. HIV envelope: challenges and opportunities for development of entry inhibitors.

8. Sulfonated Compounds Bind with Prostatic Acid Phosphatase (PAP_248-286) to Inhibit the Formation of Amyloid Fibrils.