OBJECTIVES: To identify, diagnose and counsel patients with acute HIV infection (AHI) during routine HIV testing in South Africa. METHODS: Patients with sexually transmitted infection and clients undergoing voluntary counselling and testing who were negative on rapid HIV antibody tests at a public youth clinic were recruited to the study and tested using HIV-1 PCR and third-generation ELISA. Results were made available at 1 week. Text message reminders and phone calls were employed to encourage patients to return for results. Patients with AHI were additionally visited at home. RESULTS: 902 participants were enrolled over the course of 1 year, reporting high levels of sexual risk behaviour, including 66.7% who did not use a condom at last sex. Six (0.67%) were diagnosed with AHI. Results and counselling were delivered to 62.3% of participants and all six patients with AHI. CONCLUSIONS: It is possible to perform routine diagnosis and counselling for acute HIV infection in a limited-resource setting. Provider outreach to patients may help in delivering results to a high proportion of patients, but will probably add to the already substantial cost of testing.
OBJECTIVES: To identify, diagnose and counsel patients with acute HIV infection (AHI) during routine HIV testing in South Africa. METHODS:Patients with sexually transmitted infection and clients undergoing voluntary counselling and testing who were negative on rapid HIV antibody tests at a public youth clinic were recruited to the study and tested using HIV-1 PCR and third-generation ELISA. Results were made available at 1 week. Text message reminders and phone calls were employed to encourage patients to return for results. Patients with AHI were additionally visited at home. RESULTS: 902 participants were enrolled over the course of 1 year, reporting high levels of sexual risk behaviour, including 66.7% who did not use a condom at last sex. Six (0.67%) were diagnosed with AHI. Results and counselling were delivered to 62.3% of participants and all six patients with AHI. CONCLUSIONS: It is possible to perform routine diagnosis and counselling for acute HIV infection in a limited-resource setting. Provider outreach to patients may help in delivering results to a high proportion of patients, but will probably add to the already substantial cost of testing.
Authors: JoAnn D Kuruc; Anna B Cope; Lynne A Sampson; Cynthia L Gay; Rhonda M Ashby; Evelyn M Foust; Myra Brinson; John E Barnhart; David Margolis; William C Miller; Peter A Leone; Joseph J Eron Journal: J Acquir Immune Defic Syndr Date: 2016-01-01 Impact factor: 3.731
Authors: Benjamin J Wolpaw; Catherine Mathews; Yolisa Mtshizana; Mickey Chopra; Diana Hardie; Mark N Lurie; Virginia De Azevedo; Karen Jennings Journal: PLoS One Date: 2014-08-25 Impact factor: 3.240
Authors: Sarah E Rutstein; Audrey E Pettifor; Sam Phiri; Gift Kamanga; Irving F Hoffman; Mina C Hosseinipour; Nora E Rosenberg; Dominic Nsona; Dana Pasquale; Gerald Tegha; Kimberly A Powers; Mcleod Phiri; Bisweck Tembo; Wairimu Chege; William C Miller Journal: J Acquir Immune Defic Syndr Date: 2016-03-01 Impact factor: 3.731
Authors: Simnikiwe H Mayaphi; Desmond J Martin; Thomas C Quinn; Oliver Laeyendecker; Steve A S Olorunju; Gregory R Tintinger; Anton C Stoltz Journal: PLoS One Date: 2016-10-20 Impact factor: 3.240