| Literature DB >> 20643584 |
Xuejun Gao1, Yulian Jiao, Laicheng Wang, Xiaowen Liu, Wenping Sun, Bin Cui, Zijiang Chen, Yueran Zhao.
Abstract
Antiviral activity of natural killer (NK) cells is regulated partially through inhibitory and activating killer cell immunoglobulin-like receptors (KIR) interacting with human leukocyte antigen C (HLA-C) ligands. The highly polymorphic nature of HLA-C and KIR genes endows individuals with diverse HLA-C/KIR combinations, which may confer susceptibility to or protection against a certain challenge. We analyzed the genes encoding KIR receptors and HLA-C ligands and HLA-C/KIR combinations in patients with chronic hepatitis B and healthy subjects. We found that inhibitory receptor KIR2DL1 in combination with HLA-C2 ligand confers susceptibility to chronic hepatitis B (CHB), whereas inhibitory receptor KIR2DL3 or KIR2DL3 homozygote in the presence of HLA-C1C1 genotype shows protection against CHB. Our data reveal that inhibitory NK cell interactions are important in determining antiviral immunity and that distinct affinity inhibitory responses will exert different impact on the development of CHB.Entities:
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Year: 2010 PMID： 20643584 DOI： 10.1016/j.clim.2010.05.011
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969