X He1, X Lu2, J Hu3, J Xi1, D Zhou1, H Shang1, L Liu1, H Zhou1, B Yan1, L Yu1, F Hu1, Z Liu2, L He1, X Yao2, Y Xu1. 1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province. 2. Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province. 3. Department of Neurology, Third Hospital of Hebei Medical University, Sijiazhuang, Hebei Province, China.
Abstract
BACKGROUND AND PURPOSE: The H63D polymorphism in the hemochromatosis (HFE) gene has been reported as a risk factor for amyotrophic lateral sclerosis (ALS) in Europe and America, but no data have been reported for Asia. Here, we investigated the possible association between H63D and sporadic ALS (sALS) in a Chinese Han population. METHODS: A total of 195 individuals with sALS from three centers in China and 405 unrelated healthy controls were recruited. All subjects were genotyped by restriction fragment length polymorphism (RFLP) analysis. RESULTS: Sporadic ALS was significantly related to the H63D polymorphism in heterozygous carriers (odds ratio 3.10, 95%CI: 1.49-6.47, P=0.002). CONCLUSIONS: The HFE H63D polymorphism may contribute to the development of sALS in Chinese.
BACKGROUND AND PURPOSE: The H63D polymorphism in the hemochromatosis (HFE) gene has been reported as a risk factor for amyotrophic lateral sclerosis (ALS) in Europe and America, but no data have been reported for Asia. Here, we investigated the possible association between H63D and sporadic ALS (sALS) in a Chinese Han population. METHODS: A total of 195 individuals with sALS from three centers in China and 405 unrelated healthy controls were recruited. All subjects were genotyped by restriction fragment length polymorphism (RFLP) analysis. RESULTS: Sporadic ALS was significantly related to the H63D polymorphism in heterozygous carriers (odds ratio 3.10, 95%CI: 1.49-6.47, P=0.002). CONCLUSIONS: The HFE H63D polymorphism may contribute to the development of sALS in Chinese.
Authors: Ki-Do Eum; Ryan M Seals; Kathryn M Taylor; Matthew Grespin; David M Umbach; Howard Hu; Dale P Sandler; Freya Kamel; Marc G Weisskopf Journal: Amyotroph Lateral Scler Frontotemporal Degener Date: 2014-10-08 Impact factor: 4.092