Literature DB >> 20642345

A survey of visual impairment and blindness in children attending four schools for the blind in Cambodia.

David I T Sia1, James Muecke, Michael Hammerton, Meng Ngy, Aimee Kong, Anna Morse, Martin Holmes, Horm Piseth, Carolyn Hamilton, Dinesh Selva.   

Abstract

PURPOSE: To identify the causes of blindness and severe visual impairment (BL/SVI) in children attending four schools for the blind in Cambodia and to provide spectacles, low vision aids, orientation and mobility training and ophthalmic treatment.
METHODS: Children < 16 years of age were recruited from all 4 schools for the blind in Cambodia. Causes of visual impairment and blindness were determined and categorized using World Health Organization methods.
RESULTS: Of the 95 children examined, 54.7% were blind (BL) and 10.5% were severely visually impaired (SVI). The major anatomical site of BL/SVI was the lens in 27.4%, cornea in 25.8%, retina in 21% and whole globe in 17.7%. The major underlying etiologies of BL/SVI were hereditary factors (mainly cataract and retinal dystrophies) in 45.2%, undetermined/unknown (mainly microphthalmia and anterior segment dysgenesis) in 38.7% and childhood factors in 11.3%. Avoidable causes of BL/SVI accounted for 50% of the cases; 12.9% of the total were preventable with measles being the commonest cause (8.1% of the total); 37.1% were treatable with cataracts and glaucoma being the commonest causes (22.6% and 4.8% respectively). More than 35% of children required an optical device and 27.4% had potential for visual improvement with intervention.
CONCLUSION: Half of the BL/SVI causes were potentially avoidable. The data support the need for increased coverage of measles immunization. There is also a need to develop specialized pediatric ophthalmic services for the management of surgically remediable conditions, to provide optometric, low vision and orientation and mobility services. Genetic risk counseling services also may be considered.

Entities:  

Mesh:

Year:  2010        PMID: 20642345     DOI: 10.3109/09286586.2010.489250

Source DB:  PubMed          Journal:  Ophthalmic Epidemiol        ISSN: 0928-6586            Impact factor:   1.648


  7 in total

1.  Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma.

Authors:  Kamron Khan; Adam Rudkin; David A Parry; Kathryn P Burdon; Martin McKibbin; Clare V Logan; Zakia I A Abdelhamed; James S Muecke; Narcis Fernandez-Fuentes; Kate J Laurie; Mike Shires; Rhys Fogarty; Ian M Carr; James A Poulter; Joanne E Morgan; Moin D Mohamed; Hussain Jafri; Yasmin Raashid; Ngy Meng; Horm Piseth; Carmel Toomes; Robert J Casson; Graham R Taylor; Michael Hammerton; Eamonn Sheridan; Colin A Johnson; Chris F Inglehearn; Jamie E Craig; Manir Ali
Journal:  Am J Hum Genet       Date:  2011-09-09       Impact factor: 11.025

Review 2.  Characterizing the "POAGome": A bioinformatics-driven approach to primary open-angle glaucoma.

Authors:  Ian D Danford; Lana D Verkuil; Daniel J Choi; David W Collins; Harini V Gudiseva; Katherine E Uyhazi; Marisa K Lau; Levi N Kanu; Gregory R Grant; Venkata R M Chavali; Joan M O'Brien
Journal:  Prog Retin Eye Res       Date:  2017-02-20       Impact factor: 21.198

3.  An Ophthalmic Targeted Exome Sequencing Panel as a Powerful Tool to Identify Causative Mutations in Patients Suspected of Hereditary Eye Diseases.

Authors:  Panfeng Wang; Shiqiang Li; Wenming Sun; Xueshan Xiao; Xiaoyun Jia; Mengchu Liu; Lieqiang Xu; Yuxi Long; Qingjiong Zhang
Journal:  Transl Vis Sci Technol       Date:  2019-04-25       Impact factor: 3.283

4.  Inherited Retinal Dystrophy in Southeastern United States: Characterization of South Carolina Patients and Comparative Literature Review.

Authors:  Joseph Griffith; Kareem Sioufi; Laurie Wilbanks; George N Magrath; Emil A T Say; Michael J Lyons; Meg Wilkes; Gurpur Shashidhar Pai; Mae Millicent Winfrey Peterseim
Journal:  Genes (Basel)       Date:  2022-08-20       Impact factor: 4.141

5.  Causes of severe visual impairment and blindness in children in the Republic of Suriname.

Authors:  Astrid Anna Maria Heijthuijsen; Victoria Apollonia Annemarie Beunders; Dinesh Jiawan; Anne-Marie Bueno de Mesquita-Voigt; Jerrel Pawiroredjo; Maarten Mourits; Michael Tanck; Joost Verhoeff; Peerooz Saeed
Journal:  Br J Ophthalmol       Date:  2013-04-20       Impact factor: 4.638

6.  PAX6 molecular analysis and genotype-phenotype correlations in families with aniridia from Australasia and Southeast Asia.

Authors:  Emmanuelle Souzeau; Adam K Rudkin; Andrew Dubowsky; Robert J Casson; James S Muecke; Erica Mancel; Mark Whiting; Richard A D Mills; Kathryn P Burdon; Jamie E Craig
Journal:  Mol Vis       Date:  2018-03-28       Impact factor: 2.367

7.  Identification of novel mutations causing pediatric cataract in Bhutan, Cambodia, and Sri Lanka.

Authors:  Shari Javadiyan; Sionne E M Lucas; Dechen Wangmo; Meng Ngy; Kapila Edussuriya; Jamie E Craig; Adam Rudkin; Robert Casson; Dinesh Selva; Shiwani Sharma; Karen M Lower; James Meucke; Kathryn P Burdon
Journal:  Mol Genet Genomic Med       Date:  2018-05-16       Impact factor: 2.183

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.