AIMS: Known collectively as serrated polyps, hyperplastic polyps (HP), sessile serrated adenomas (SSA/SSP) and traditional serrated adenoma (TSA) may represent a spectrum of increasing malignant potential with characteristic immunological markers. There is increasing evidence that HP, SSA/SSP and TSA are biologically different and are likely to represent a spectrum along the serrated polyp pathway. Although there is general consensus about the diagnostic features of serrated polyps, the morphological differences between the categories are often subtle. This study compares the expression of p53 and P504S among serrated polyps. Sixty seven randomly selected biopsies (n = 59) and resection specimens (n = 8) histologically diagnosed for SSA/SSP, TSA and HP (19, 30 and 18 specimens, respectively) were obtained. METHODS AND RESULTS: There was a significant difference in p53 (P < 0.001) and P504S (P < 0.001) immunopositivity and distribution among the serrated polyps. In particular, there is diffuse expression p53 and P504S in TSA compared to HP and SSA/SSP where p53 and P504S expression was more frequently confined to the lower 1/3 of the crypts. In addition, percentage of cells expressing p53 and p504S expression was higher in TSA than those of HP and SSA/SSP. CONCLUSION: Immunostains, p53 and P504S, may be useful adjuncts to morphological diagnosis of serrated polyps.
AIMS: Known collectively as serrated polyps, hyperplastic polyps (HP), sessile serrated adenomas (SSA/SSP) and traditional serrated adenoma (TSA) may represent a spectrum of increasing malignant potential with characteristic immunological markers. There is increasing evidence that HP, SSA/SSP and TSA are biologically different and are likely to represent a spectrum along the serrated polyp pathway. Although there is general consensus about the diagnostic features of serrated polyps, the morphological differences between the categories are often subtle. This study compares the expression of p53 and P504S among serrated polyps. Sixty seven randomly selected biopsies (n = 59) and resection specimens (n = 8) histologically diagnosed for SSA/SSP, TSA and HP (19, 30 and 18 specimens, respectively) were obtained. METHODS AND RESULTS: There was a significant difference in p53 (P < 0.001) and P504S (P < 0.001) immunopositivity and distribution among the serrated polyps. In particular, there is diffuse expression p53 and P504S in TSA compared to HP and SSA/SSP where p53 and P504S expression was more frequently confined to the lower 1/3 of the crypts. In addition, percentage of cells expressing p53 and p504S expression was higher in TSA than those of HP and SSA/SSP. CONCLUSION: Immunostains, p53 and P504S, may be useful adjuncts to morphological diagnosis of serrated polyps.
Authors: Kevin J Spring; Zhen Zhen Zhao; Rozemary Karamatic; Michael D Walsh; Vicki L J Whitehall; Tanya Pike; Lisa A Simms; Joanne Young; Michael James; Grant W Montgomery; Mark Appleyard; David Hewett; Kazutomo Togashi; Jeremy R Jass; Barbara A Leggett Journal: Gastroenterology Date: 2006-08-18 Impact factor: 22.682
Authors: Sun M Chung; Yao-Tseng Chen; Andrea Panczykowski; Neal Schamberg; David S Klimstra; Rhonda K Yantiss Journal: Am J Surg Pathol Date: 2008-03 Impact factor: 6.394
Authors: Baojin Fu; Shinichi Yachida; Richard Morgan; Yi Zhong; Elizabeth A Montgomery; Christine A Iacobuzio-Donahue Journal: Am J Clin Pathol Date: 2012-09 Impact factor: 2.493
Authors: Douglas K Rex; Dennis J Ahnen; John A Baron; Kenneth P Batts; Carol A Burke; Randall W Burt; John R Goldblum; José G Guillem; Charles J Kahi; Matthew F Kalady; Michael J O'Brien; Robert D Odze; Shuji Ogino; Susan Parry; Dale C Snover; Emina Emilia Torlakovic; Paul E Wise; Joanne Young; James Church Journal: Am J Gastroenterol Date: 2012-06-19 Impact factor: 10.864