BACKGROUND: Increased peritoneal solute transport rate (PSTR) is primarily a consequence of continuous exposure to bioincompatible glucose-based peritoneal dialysis (PD) solutions. However, relationships between increasing PSTR and dialysate glucose load remain unclear. As some PD patients with preserved residual renal function do not show increased PSTR despite long-term PD, we examined whether loss of residual renal function is associated with increased PSTR on long-term PD. METHODS: We evaluated 35 patients who started PD between 1997 and 2002 and received continuous PD treatment for >6 years. Data included baseline clinical data, residual renal function, urea and creatinine clearance, dialysate glucose load, ultrafiltration, and the use of icodextrin and renin-angiotensin system inhibitors. Peritoneal equilibration test results and data were collected annually for 6 years. RESULTS: Both the glomerular filtration rate and urine volume at 6 years on PD showed significant negative correlations with the dialysate-to-plasma creatinine ratio (D/P Cr) at 6 years (r = -0.716 and r = -0.717, respectively). Multivariate analysis showed only urine volume at 6 years on PD as an independent covariate of the D/P Cr at 6 years on PD. CONCLUSIONS: Loss of residual renal function is directly associated with increased PSTR in patients on long-term PD.
BACKGROUND: Increased peritoneal solute transport rate (PSTR) is primarily a consequence of continuous exposure to bioincompatible glucose-based peritoneal dialysis (PD) solutions. However, relationships between increasing PSTR and dialysate glucose load remain unclear. As some PDpatients with preserved residual renal function do not show increased PSTR despite long-term PD, we examined whether loss of residual renal function is associated with increased PSTR on long-term PD. METHODS: We evaluated 35 patients who started PD between 1997 and 2002 and received continuous PD treatment for >6 years. Data included baseline clinical data, residual renal function, urea and creatinine clearance, dialysate glucose load, ultrafiltration, and the use of icodextrin and renin-angiotensin system inhibitors. Peritoneal equilibration test results and data were collected annually for 6 years. RESULTS: Both the glomerular filtration rate and urine volume at 6 years on PD showed significant negative correlations with the dialysate-to-plasma creatinine ratio (D/P Cr) at 6 years (r = -0.716 and r = -0.717, respectively). Multivariate analysis showed only urine volume at 6 years on PD as an independent covariate of the D/P Cr at 6 years on PD. CONCLUSIONS: Loss of residual renal function is directly associated with increased PSTR in patients on long-term PD.
Authors: Imad Siddique; K Scott Brimble; Louise Walkin; Angela Summers; Paul Brenchley; Sarah Herrick; Peter J Margetts Journal: Perit Dial Int Date: 2014-11-13 Impact factor: 1.756
Authors: Dorota Sikorska; Krzysztof Pawlaczyk; Anna Olewicz-Gawlik; Natasza Czepulis; Bartlomiej Posnik; Ewa Baum; Maria Wanic-Kossowska; Bengt Lindholm; Andrzej Oko Journal: Int Urol Nephrol Date: 2016-10-12 Impact factor: 2.370