Literature DB >> 20639110

Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus.

Yu Luo1, Jia-Ping Yao, Li Yang, Chun-Lan Feng, Wei Tang, Gui-Feng Wang, Jian-Pin Zuo, Wei Lu.   

Abstract

A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50<0.41 microM and SI>81.2, was the most promising compound and selected as the benchmark compound for further optimization. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20639110     DOI： 10.1016/j.bmc.2010.05.076

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  7 in total

1.  Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro.

Authors:  Vishal M Balaramnavar; Khurshid Ahmad; Mohd Saeed; Irfan Ahmad; Mehnaz Kamal; Talaha Jawed
Journal:  RSC Adv       Date:  2020-11-04       Impact factor: 4.036

2.  Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues.

Authors:  Sumit Tahlan; Kalavathy Ramasamy; Siong Meng Lim; Syed Adnan Ali Shah; Vasudevan Mani; Balasubramanian Narasimhan
Journal:  Chem Cent J       Date:  2018-12-19       Impact factor: 4.215

Review 3.  Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review.

Authors:  Sumit Tahlan; Sanjiv Kumar; Balasubramanian Narasimhan
Journal:  BMC Chem       Date:  2019-08-06

4.  New Triazinoindole Bearing Benzimidazole/Benzoxazole Hybrids Analogs as Potent Inhibitors of Urease: Synthesis, In Vitro Analysis and Molecular Docking Studies.

Authors:  Sundas Mumtaz; Shahid Iqbal; Mazloom Shah; Rafaqat Hussain; Fazal Rahim; Wajid Rehman; Shoaib Khan; Obaid-Ur-Rahman Abid; Liaqat Rasheed; Ayed A Dera; Hanan A Al-Ghulikah; Sana Kehili; Eslam B Elkaeed; Hamad Alrbyawi; Mohammed Issa Alahmdi
Journal:  Molecules       Date:  2022-10-04       Impact factor: 4.927

5.  Small Molecule Derived From Carboxyethylpyrrole Protein Adducts Promotes Angiogenesis in a Mouse Model of Peripheral Arterial Disease.

Authors:  Luqia Hou; Guang Yang; Shibing Tang; Cynthia Alcazar; Prajakta Joshi; Zachary Strassberg; Michael Kim; Masashi Kawamura; Y Joseph Woo; Joseph Shrager; Sheng Ding; Ngan F Huang
Journal:  J Am Heart Assoc       Date:  2018-09-18       Impact factor: 5.501

6.  Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents.

Authors:  Cheng-Ying Hsieh; Pi-Wen Ko; Yu-Jui Chang; Mohit Kapoor; Yu-Chuan Liang; Hui-Hsien Lin; Jia-Cherng Horng; Ming-Hua Hsu
Journal:  Molecules       Date:  2019-09-06       Impact factor: 4.411

7.  Treatment with a new benzimidazole derivative bearing a pyrrolidine side chain overcomes sorafenib resistance in hepatocellular carcinoma.

Authors:  Fat-Moon Suk; Chao-Lien Liu; Ming-Hua Hsu; Yu-Ting Chuang; Jack P Wang; Yi-Jen Liao
Journal:  Sci Rep       Date:  2019-11-21       Impact factor: 4.379
  7 in total

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