| Literature DB >> 20638904 |
Sanjeev Krishna1, Serena Pulcini, Farrah Fatih, Henry Staines.
Abstract
With the advent of artemisinin resistance, it is timely to revisit the biological basis for the controversial suggestion that this class of antimalarial exerts its activity by inhibiting a calcium ATPase (PfATP6) that is most similar to sarcoplasmic endoplasmic reticulum calcium ATPases (SERCAs). Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere.Entities:
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Year: 2010 PMID： 20638904 DOI： 10.1016/j.pt.2010.06.014
Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922