| Literature DB >> 20638379 |
Azad A Ahanger1, Shahid Prawez, Marie Dennis Marcus Leo, Kandaswamy Kathirvel, Dinesh Kumar, Surendra K Tandan, Jitendra K Malik.
Abstract
Hemin induces heme oxygenase (HO), an enzyme which degrades heme in a rate-limiting manner and has an important role in cellular protection against oxidative stress and apoptosis. This HO inducer may be of potential therapeutic value in wound healing and inflammation. To identify the beneficial activity of HO vis a vis wound healing, hemin was used as inducer of HO in rats using a full-thickness cutaneous wound model. Hemin treatment increased cellular proliferation and collagen synthesis as evidenced by increase in wound contraction and hydroxyproline and glucosamine contents. mRNA expression of cytokines endorsed fast healing as was indicated by inhibition of pro-inflammatory cytokines such as ICAM-1 and TNF-alpha and up-regulation of anti-inflammatory cytokine IL-10. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20638379 DOI： 10.1016/j.ejphar.2010.06.048
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432